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The aetiopathogenesis of vaccine-induced immune thrombotic thrombocytopenia

Cheng-Hock Toh1, Guozheng Wang2, Alan L Parker3

  • 1University of Liverpool, Liverpool, UK c.h.toh@liverpool.ac.uk.

Clinical Medicine (London, England)
|March 11, 2022
PubMed

In the new science emanating from the COVID-19 pandemic, effective vaccine development has made a huge difference and saved countless lives. Vaccine roll-out led to the identification of rare cases of severe thrombotic and thrombocytopenic problems in some recipients. This apparent coupling of thrombosis with haemorrhagic potentiation might seem baffling but the ensuing clinical investigation rapidly shed important light on its molecular mechanism. This review outlines the current understanding on the role of adenovirus-based platforms, the immunogenic triggers and the immunothrombotic response underlying vaccine-induced immune thrombotic thrombocytopenia.

Keywords:
COVID-19Fc-gamma-RIIaadenovirus vaccinesplatelet factor-4vaccine-induced immune thrombotic thrombocytopenia

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