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Updated: Sep 30, 2025

Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation
08:10

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Clinical Utility of Left Atrial Asynchrony and Mechanical Function in Patients with Hypertrophic Cardiomyopathy

Ozkan Candan1, Cetin Gecmen2, Muzaffer Kahyaoğlu2

  • 1Cardiology Clinic, Usak University, Faculty of Medicine, Usak.

Acta Cardiologica Sinica
|March 11, 2022
PubMed

Insights

In hypertrophic cardiomyopathy patients, increased atrial dispersion and reduced peak atrial longitudinal strain predict atrial fibrillation development. Age is also a key predictor, highlighting the importance of these echocardiographic measures for risk assessment.

Area of Science:

  • Cardiology
  • Medical Imaging
  • Echocardiography

Background:

  • Hypertrophic cardiomyopathy (HCM) is a significant risk factor for cardiovascular complications.
  • Atrial fibrillation (AF) is a common complication in HCM patients, increasing morbidity and mortality.
  • Predictive markers for AF development in HCM are crucial for timely intervention.

Purpose of the Study:

  • To investigate left atrial dispersion and strain using speckle tracking echocardiography as predictors of AF in HCM patients.
  • To assess the role of clinical parameters alongside echocardiographic findings in predicting AF development.

Main Methods:

  • A cohort of 151 HCM patients underwent comprehensive clinical and speckle tracking echocardiographic assessments.
  • Atrial dispersion was quantified as the standard deviation of time to peak strain in 12 left atrial segments.
  • AF development was monitored via electrocardiograms and Holter recordings during follow-up.

Main Results:

  • 26% of patients developed AF during follow-up.
  • Lower peak atrial longitudinal strain and higher atrial dispersion were significantly associated with AF development.
  • Multivariate analysis identified atrial dispersion, peak atrial longitudinal strain, and age as independent predictors of AF.

Conclusions:

  • Atrial dispersion and peak atrial longitudinal strain are significant predictors of AF in patients with hypertrophic cardiomyopathy.
  • Speckle tracking echocardiography-derived atrial dispersion offers valuable insights into left atrial function in HCM.
  • These echocardiographic parameters can aid in stratifying AF risk in HCM patients.
Abstract

Keywords:
Atrial dispersionAtrial fibrillationHypertrophic cardiomyopathySpeckle tracking echocardiography

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