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Updated: Sep 30, 2025

Neuronavigated Focalized Transcranial Direct Current Stimulation Administered During Functional Magnetic Resonance Imaging

Neuronavigated Focalized Transcranial Direct Current Stimulation Administered During Functional Magnetic Resonance Imaging

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The Predictive Value of Individual Electric Field Modeling for Transcranial Alternating Current Stimulation Induced

Basil C Preisig^1,2,3,4, Alexis Hervais-Adelman^1,4

¹Department of Psychology, Neurolinguistics, University of Zurich, Zurich, Switzerland.

Frontiers in Cellular Neuroscience

|March 11, 2022

Summary

This summary is machine-generated.

Individual differences in electric field strength from transcranial alternating current stimulation (tACS) predict brain activity and connectivity changes. This dose-response relationship, particularly in the right hemisphere, highlights the impact of neuroanatomy on tACS effectiveness.

Keywords:

connectivity dichotic listening electric field modeling fMRI transcranial alternating current stimulation (tACS)

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Last Updated: Sep 30, 2025

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Published on: August 20, 2019

Area of Science:

Neuroscience
Neuroimaging
Computational Neuroscience

Background:

Individual variability in non-invasive brain stimulation effectiveness is often attributed to anatomical differences affecting the induced electric field.
Understanding this relationship is crucial for optimizing transcranial alternating current stimulation (tACS) protocols.

Purpose of the Study:

To investigate whether individual differences in the induced electric field predict neurophysiological and behavioral outcomes of gamma band tACS.
To explore the relationship between electric field strength and precision with tACS-induced changes in brain activity and connectivity.

Main Methods:

A within-subject experiment using bi-hemispheric gamma band tACS with varying interhemispheric phase lags and sham stimulation.
Concurrent functional magnetic resonance imaging (fMRI) and a dichotic listening task to measure auditory brain activity.
Individualized electric field modeling based on T1 structural MRI to derive strength and precision metrics.

Main Results:

Significant individual variability was observed in electric field strength and precision.
Electric field strength in the right hemisphere significantly predicted individual differences in tACS-induced brain connectivity changes.
A statistical trend indicated electric field strength influenced tACS-induced BOLD signal changes in both hemispheres.

Conclusions:

Evidence supports a dose-response relationship between individual electric field characteristics and tACS-induced neurophysiological changes measured with fMRI.
The stronger effect in the right hemisphere suggests hemispheric asymmetries in the relationship between electric fields and tACS outcomes.
Electric field strength, not precision, emerged as a key predictor of tACS-induced effects on brain activity and connectivity.