[Dobutamine in vascular surgery]

The hemodynamic parameters of 12 patients operated on not a coronary vascular disease have been controlled by means of not invasive technic. The aortic output was measured by means of an oesophageal probe that associates echography and Doppler effect. A double blinded study was done by dividing the patients into two groups. The group 1 was subjected to a perfusion of dobutamine and the group 2 to a perfusion of a placebo during the operation. The group 1 showed a mean aortic output similar-level than before anesthesia one (3.40 +/- 0.61 l/min; 3.35 +/- 0.5 l/min) and 37% greater than group 2 (p less than 0.01), during operation period. The average systolic volume of group 1 was nearly similar at the initial one (46.5 +/- 12.92 ml; 40.8 +/- 8.2 ml) and 35% higher than group 2 (p less than 0.01). The cardiac frequency was higher (average 14 beats per minute) in the group 1 (p less than 0.01). The total systemic vascular resistance of group 1 were maintained in equilibrium and did not show any significative change. In opposition, group 2 showed a 207% increase in their vascular resistance, in relation to the initial values (p less than 0.01). These values were significatively higher that those of the group 1 (p less than 0.00). Mean diuresis was of 144 +/- 41.5 ml/h for group 1 and 43.6 +/- 10.9 ml/h for group 2 (p less than 0.001). In group 2 the H+ concentration increased from 33 to 39 nmol/l (p less than 0.01) and it was higher (p less than 0.01) than group 1.(ABSTRACT TRUNCATED AT 250 WORDS)