Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Endocarditis II: Clinical Features of Infective Endocarditis

Endocarditis II: Clinical Features of Infective Endocarditis

Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...

Prosopagnosia

Prosopagnosia

Prosopagnosia, also known as face blindness, is the inability to recognize faces. In severe cases, individuals with prosopagnosia may not recognize close family members, including parents and spouses, by their faces. For instance, someone with prosopagnosia might walk past their child in a crowd, only realizing their mistake upon noticing their child's distinctive backpack or favorite jacket. Prosopagnosia specifically impairs facial recognition, while the recognition of other objects or...

Photoreceptors and Visual Pathways

Photoreceptors and Visual Pathways

At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Wound healing, scarring and management.

Clinical and experimental dermatology·2023

Same author

Axillary dissection versus axillary observation for low risk, clinically node-negative invasive breast cancer: a systematic review and meta-analysis.

Breast cancer (Tokyo, Japan)·2021

Same author

HLA Immunogenotype Determines Persistent Human Papillomavirus Virus Infection in HIV-Infected Patients Receiving Antiretroviral Treatment.

The Journal of infectious diseases·2016

Same author

Ex-vivo recognition of late-lytic CD8 epitopes specific for Kaposi's sarcoma-associated herpesvirus (KSHV) by HIV/KSHV-coinfected individuals.

Viral immunology·2011

Same author

Evaluation of a novel broad-spectrum PCR-multiplex genotyping assay for identification of cutaneous wart-associated human papillomavirus types.

Journal of clinical microbiology·2010

Same journal

A diagnostic headache: A rare case of adult onset primary leptomeningeal medulloblastoma.

SAGE open medical case reports·2026

Same journal

Delayed diagnosis of pancake kidney (completely fused pelvic renal ectopia) in a 49-year-old woman presenting with lower urinary tract symptoms in a low-resource setting: A case report.

SAGE open medical case reports·2026

Same journal

Takotsubo syndrome triggered by perioperative and post-resuscitation stress: Case report.

SAGE open medical case reports·2026

Same journal

Normocalcemic pseudohypoparathyroidism type 1B complicated by hypokalemia: A case report.

SAGE open medical case reports·2026

Same journal

Angiomatoid fibrous histiocytoma with CDK4 and MDM2 expression misdiagnosed as dedifferentiated liposarcoma: The first case report and literature review.

SAGE open medical case reports·2026

Same journal

Treatment of gastrocnemius spasms induced by foot injury using negative pressure wound therapy: A case report.

SAGE open medical case reports·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Sep 30, 2025

Iris Fixation via External Pentagram Suturing

Iris Fixation via External Pentagram Suturing

Published on: May 5, 2022

Orange palpebral spots: A case presentation.

Mahaveer S Sangha¹, Hazem Ah Ibrahim², Rhonda Meys²

¹University College London Medical School, London, UK.

SAGE Open Medical Case Reports

|March 11, 2022

Summary

This summary is machine-generated.

This study reports the first case of orange palpebral spots in the UK, a rare eyelid condition. The findings suggest a potential link between sun exposure and the development of these spots.

Keywords:

Orange lipofuscin orange palpebral macules orange palpebral spots periocular solar elastosis sun damage

More Related Videos

Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration

Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration

Published on: May 26, 2023

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

Related Experiment Videos

Last Updated: Sep 30, 2025

Iris Fixation via External Pentagram Suturing

Iris Fixation via External Pentagram Suturing

Published on: May 5, 2022

Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration

Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration

Published on: May 26, 2023

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

Area of Science:

Ophthalmology
Dermatology
Pathology

Background:

Orange palpebral spots are rare, bilateral, orange-yellow macules on the superior eyelids, typically seen in Caucasian populations.
Previous research linked them to melatonin incontinence, lipofuscin, and specific vitamin/carotenoid levels.

Observation:

A 59-year-old male in the UK presented with a nasal lesion, and bilateral orange-yellow eyelid discoloration was incidentally noted during Mohs surgery.
The patient had a history of atopy, significant sun exposure, cataracts, and retinal detachment, but no unusual dietary intake of pigments.

Findings:

Skin biopsy confirmed orange palpebral spots, showing epidermal thinning, superficial mature fat cells, minimal pigment incontinence, and solar elastosis.
Histological findings suggest a potential role for sun exposure in the pathogenesis of this condition.

Implications:

This case expands the known geographical distribution of orange palpebral spots.
Further research is needed to elucidate the pathogenesis, with sun exposure identified as a potential contributing factor.