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Related Concept Videos

Mitral Stenosis I: Introduction01:22

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Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
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Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
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Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
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Updated: Sep 30, 2025

Hemodynamic Precision in the Neonatal Intensive Care Unit using Targeted Neonatal Echocardiography
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DSPECT-specific normative limits for left ventricular size and function.

Joseph Ibrahim1, Ricardo A Nieves2, Amr F Barakat2

  • 1Department of Internal Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology
|March 11, 2022
PubMed
Summary
This summary is machine-generated.

This study establishes normal left ventricular (LV) measurement values using DSPECT-SPECT imaging in healthy organ donors. These DSPECT-specific normal values are crucial for accurate myocardial perfusion imaging interpretation.

Keywords:
MPISPECTTests

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Area of Science:

  • Cardiology
  • Nuclear Medicine
  • Medical Imaging

Background:

  • Differences in spatial resolution and image filtering between DSPECT and traditional Anger SPECT cameras impact left ventricular (LV) measurements.
  • DSPECT-specific normal values for LV measurements are currently unavailable.
  • Traditional methods for deriving normal values using patients with low coronary artery disease probability have limitations.

Purpose of the Study:

  • To establish DSPECT-specific normal values for left ventricular (LV) measurements.
  • To provide normative data for accurate interpretation of myocardial perfusion imaging (MPI) using DSPECT technology.

Main Methods:

  • Ninety-two healthy kidney or liver donors without known cardiac disease or medications underwent Tc-99m sestamibi-gated SPECT MPI on a DSPECT camera.
  • Rest (5 mCi) and stress (15 mCi) imaging was performed for pre-operative evaluation.
  • Left ventricular (LV) measurements were obtained from post-stress supine images using QGS® software.

Main Results:

  • Mean ejection fraction (EF) ± 2SD for women and men was 77.2% ± 14.1% and 70.0% ± 14.7%, respectively.
  • Mean end-diastolic volume (EDV) ± 2SD (indexed) for women and men was 67.0 ± 32.2 mL (38.3 ± 17.2 mL/m²) and 99.6 ± 51.6 mL (48.1 ± 25.9 mL/m²), respectively.
  • Mean end-systolic volume (ESV) ± 2SD (indexed) for women and men was 16.1 ± 15.7 mL (9.2 ± 8.8 mL/m²) and 31.2 ± 29.2 mL (15.0 ± 14.2 mL/m²), respectively.

Conclusions:

  • This study reports DSPECT-specific LV measurements derived from healthy organ donors.
  • The established normal values can be utilized for clinical interpretation of DSPECT myocardial perfusion imaging.
  • Healthy organ donors are a suitable population for deriving normal values for cardiac imaging.