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Antibody-mediated targeting in the treatment and diagnosis of cancer: an overview
Abstract:
Enhancing the discrimination between tumour and host has been an underlying goal of efforts to improve the diagnosis and treatment of cancer. Over the past 15 years considerable interest has focussed upon targeting systems designed to permit selective delivery of a variety of agents, including drugs, radioisotopes and toxins, to tumours, for both diagnosis and therapy. A vast body of information has accumulated on this subject, and considerable emphasis has been placed on the use of antibodies as carriers, as at present they offer the greatest clinical potential. Many targeting systems have been evaluated in vitro and in pre-clinical models, but few, with the exception of antibody-radioisotope conjugates, have been evaluated in patients. However, systematic evaluation of the therapeutic potential of immunoconjugates in the clinic is planned or already under way. While reviews of some individual aspects of antibody targeting do exist, there are none that encompass this entire field. Our objective is to fill this gap with a concise overview of antibody-mediated targeting for diagnostic and therapeutic applications.
Insights
Antibody-mediated targeting enhances cancer diagnosis and therapy by selectively delivering agents to tumors. This review provides a comprehensive overview of antibody targeting systems for improved cancer care.
Area of Science:
- Oncology
- Immunology
- Biotechnology
Background:
- Distinguishing tumors from host tissues is crucial for cancer diagnosis and treatment.
- Targeting systems for selective delivery of therapeutic and diagnostic agents to tumors have gained significant interest.
- Antibodies are a primary focus due to their high clinical potential in targeted delivery.
Purpose of the Study:
- To provide a comprehensive overview of antibody-mediated targeting for cancer diagnosis and therapy.
- To consolidate existing knowledge on antibody targeting systems.
- To address the gap in comprehensive reviews of this field.
Main Methods:
- Review of existing literature on antibody targeting systems.
- Focus on antibody-mediated delivery of drugs, radioisotopes, and toxins.
- Evaluation of in vitro, pre-clinical, and clinical studies.
Main Results:
- Extensive research has been conducted on antibody targeting systems over the past 15 years.
- Antibody-radioisotope conjugates are among the few systems evaluated in patients.
- Systematic clinical evaluation of immunoconjugates is underway.
Conclusions:
- Antibody-mediated targeting holds significant promise for improving cancer diagnosis and therapy.
- Further clinical evaluation of immunoconjugates is essential.
- This review offers a unified perspective on antibody targeting applications in oncology.