A study of structure-activity relationship and anion-controlled quinolinyl Ag(I) complexes as antimicrobial and...

In this communication, we feature the synthesis and in-depth characterization of a series of silver(I) complexes obtained from the complexation of quinolin-4-yl Schiff base ligands ((E)-2-((quinolin-4-ylmethylene)amino)phenol L_a, 2-(quinolin-4-yl)benzo[d]thiazole L_b, (E)-N-(2-fluorophenyl)-1-(quinolin-4-yl)methanimine L_c, (E)-N-(4-chlorophenyl)-1-(quinolin-4-yl)methanimine L_d, (E)-1-(quinolin-4-yl)-N-(p-tolyl)methanimine L_e, (E)-1-(quinolin-4-yl)-N-(thiophen-2-ylmethyl)methanimine L_f) and three different silver(I) anions (nitrate, perchlorate and triflate). Structurally, the complexes adopted different coordination geometries, which included distorted linear or distorted tetrahedral geometry. The complexes were evaluated in vitro for their potential antibacterial and antioxidant activities. In addition, their interactions with calf thymus-DNA (CT-DNA) and bovine serum albumin (BSA) were evaluated. All the complexes had a wide spectrum of effective antibacterial activity against gram-positive and gram-negative bacterial and good antioxidant properties. The interactions of the complexes with CT-DNA and BSA were observed to occur either through intercalation or through a minor groove binder, while the interaction of the complexes with BSA reveals that some of the complexes can strongly quench the fluorescence of BSA through the static mechanism. The molecular docking studies of the complexes were also done to further elucidate the modes of interaction with CT-DNA and BSA.