Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Alzheimer's Disease: Treatment01:22

Alzheimer's Disease: Treatment

278
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
278
Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

711
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
711
Dementia01:30

Dementia

204
Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
204
Strategies for Assessing and Addressing Confounding01:25

Strategies for Assessing and Addressing Confounding

169
Confounding is a critical issue in epidemiological studies, often leading to misleading conclusions about associations between exposures and outcomes. It occurs when the relationship between the exposure and the outcome is mixed with the effects of other factors that influence the outcome. Given that, addressing confounding is of high importance for drawing accurate inferences in research.
Confounding can be addressed at both the design phase of a study and through analytical methods after data...
169
Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

113
Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
113
Levels of Health Promotion and Illness Prevention01:26

Levels of Health Promotion and Illness Prevention

13.5K
Health promotion allows a person to control the determinants of health, resulting in an improved health status. It enhances the quality of life and reduces premature deaths. Health promotion and illness prevention programs help people make beneficial choices to reduce the risk of disease and disabilities. There are three health promotion and illness prevention levels: primary, secondary, and tertiary prevention.
In primary prevention, actions taken before disease onset prevent the disease from...
13.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Survival estimates and their predictors in genetic frontotemporal dementia: an international, retrospective, cohort study.

The Lancet. Neurology·2026
Same author

Shifting the emphasis of brain health literacy from individuals to systems to reduce inequalities.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

Reply to the Letter to the Editor: Editorial: AI-assisted Letters to the Editor-Scope of a Growing Ethical and Practical Concern, and CORR's Approach to Managing It.

Clinical orthopaedics and related research·2026
Same author

Lessons from a 'low-tech' community approach to youth mental health in Argentina: shared space, purpose and stories.

Lancet regional health. Americas·2026
Same author

The principles of Population-Level Approaches to Dementia Risk Reduction (PLADRR).

PLoS medicine·2026
Same author

Expanding the scope of collective responsibility in neuro-oncology: The integrity of the published record.

Neuro-oncology·2026

Related Experiment Video

Updated: Sep 30, 2025

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
12:18

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment

Published on: January 11, 2020

7.6K

Avoiding Over-Reliance on Multi-Domain Interventions for Dementia Prevention.

Timothy Daly1,2, Ignacio Mastroleo2,3, Raffaella Migliaccio4,5,6

  • 1Sorbonne Université, Science Norms Democracy, UMR 8011, Paris, France.

Journal of Alzheimer'S Disease : JAD
|March 11, 2022
PubMed
Summary

Non-pharmacological risk reduction (RR) offers an alternative to Alzheimer's disease treatments. However, over-reliance on multi-domain interventions may limit individual impact, focus too much on later life, and ignore social determinants of dementia.

Keywords:
Alzheimer’s diseasedementiahealth inequitiesmultidomain interventionspublic healthrisk reductionsocial determinants of health

More Related Videos

Dual-Task Stroop Paradigm for Detecting Cognitive Deficits in High-Functioning Stroke Patients
07:42

Dual-Task Stroop Paradigm for Detecting Cognitive Deficits in High-Functioning Stroke Patients

Published on: December 16, 2022

3.1K
Highlighting and Reducing the Impact of Negative Aging Stereotypes During Older Adults' Cognitive Testing
06:58

Highlighting and Reducing the Impact of Negative Aging Stereotypes During Older Adults' Cognitive Testing

Published on: January 24, 2020

7.4K

Related Experiment Videos

Last Updated: Sep 30, 2025

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
12:18

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment

Published on: January 11, 2020

7.6K
Dual-Task Stroop Paradigm for Detecting Cognitive Deficits in High-Functioning Stroke Patients
07:42

Dual-Task Stroop Paradigm for Detecting Cognitive Deficits in High-Functioning Stroke Patients

Published on: December 16, 2022

3.1K
Highlighting and Reducing the Impact of Negative Aging Stereotypes During Older Adults' Cognitive Testing
06:58

Highlighting and Reducing the Impact of Negative Aging Stereotypes During Older Adults' Cognitive Testing

Published on: January 24, 2020

7.4K

Area of Science:

  • Neuroscience
  • Public Health
  • Gerontology

Background:

  • Alzheimer's disease (AD) pathology targeting has unknown therapeutic value.
  • Robust dementia risk factors are being discovered.
  • Non-pharmacological risk reduction (RR) is emerging as an alternative strategy.

Purpose of the Study:

  • To address potential issues with over-reliance on multi-domain interventions for dementia risk reduction.
  • To advocate for a broader discussion on therapeutic avenues for dementia.

Main Methods:

  • Conceptual analysis of current risk reduction strategies.
  • Identification of limitations in multi-domain intervention approaches.
  • Discussion of social determinants of dementia.

Main Results:

  • Over-reliance on multi-domain interventions may have limited individual impact.
  • Current RR approaches may excessively focus on later life interventions.
  • Social determinants of dementia are often overlooked in risk reduction strategies.

Conclusions:

  • While RR is valuable for public health, a balanced approach is needed.
  • Addressing dementia requires exploring diverse therapeutic avenues beyond solely multi-domain interventions.
  • Further research and societal debate are crucial for comprehensive dementia prevention and management.