Related Experiment Video
Updated: Sep 30, 2025
12:01
Detection of Disease-associated α-synuclein by Enhanced ELISA in the Brain of Transgenic Mice Overexpressing Human A53T Mutated α-synuclein
Published on: May 30, 2015
10.9K
Cardiac Alpha-Synuclein Is Present in Alpha-Synucleinopathies
Keivan Javanshiri1, Tove Drakenberg1, Mattias Haglund1
1Department of Clinical Sciences Lund, Division of Pathology, Lund University, Lund, Sweden.
Journal of Parkinson'S Disease
|March 11, 2022
Summary
Alpha-synucleinopathies (AS) show significant cardiac alpha-synuclein (α-syn) pathology. This study confirms α-syn presence in the heart of AS patients, unlike controls, suggesting further cardiac function research.
Area of Science:
- Neuropathology
- Neurodegenerative Diseases
- Cardiovascular Pathology
Background:
- Alpha-synucleinopathies (AS) involve alpha-synuclein (α-syn) aggregation in the central nervous system.
- AS includes dementia with Lewy bodies, Parkinson's disease, and multiple system atrophy.
- Previous research indicated α-syn pathology in the peripheral nervous system, including the heart.
Purpose of the Study:
- To investigate and confirm cardiac α-syn presence in AS patients.
- To compare cardiac α-syn in AS versus other neurocognitive disorders.
- To utilize a neuropathologically confirmed cohort for accuracy.
Main Methods:
- Inclusion of deceased patients with confirmed AS and autopsy data (2010-2021).
- Exclusion of cases with inadequate cardiac tissue or limited neuropathology.
- Immunohistochemistry used to detect cardiac α-syn aggregates in 68 AS and 32 age-matched control cases.
Main Results:
- A significantly higher prevalence of cardiac α-syn pathology was observed in the AS group (82%) compared to the control group (0%).
- Statistical analysis confirmed the significant difference (p≤0.001).
Conclusions:
- This study confirms a strong association between alpha-synucleinopathies and cardiac α-syn pathology.
- The findings warrant further investigation into the pathophysiological impact of cardiac α-syn on heart function in AS patients.
Related Concept Videos
01:37Neural Regulation
40.4K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
40.4K
03:03Amyloid Fibrils
10.2K
Amyloid fibrils are aggregates of misfolded proteins. Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils.
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining,...
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining,...
10.2K
01:29Cardiomyopathy III: Hypertrophic Cardiomyopathy
78
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
78
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
244
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
244
01:15Parkinson's Disease: Overview
786
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
786