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Related Experiment Video

Updated: Sep 30, 2025

Generation of Electronic Cigarette Aerosol by a Third-Generation Machine-Vaping Device: Application to Toxicological Studies

Generation of Electronic Cigarette Aerosol by a Third-Generation Machine-Vaping Device: Application to Toxicological Studies

Published on: August 25, 2018

Assessing variability of aerosols generated from e-Cigarettes.

Darpan Das¹, Sarah-Marie Alam El Din¹, Jairus Pulczinski¹

¹Department of Environmental Health and Engineering, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.

Inhalation Toxicology

|March 11, 2022

Summary

E-cigarette aerosol properties vary significantly between devices and experiments. This variability, often due to poor quality control, highlights the need for standardized methods in e-cigarette research.

Keywords:

Vaping; variability aerosols in vivo

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Last Updated: Sep 30, 2025

Generation of Electronic Cigarette Aerosol by a Third-Generation Machine-Vaping Device: Application to Toxicological Studies

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Published on: August 25, 2018

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Comparing the Effects of Electronic Cigarette Vapor and Cigarette Smoke in a Novel In Vivo Exposure System

Comparing the Effects of Electronic Cigarette Vapor and Cigarette Smoke in a Novel In Vivo Exposure System

Published on: May 24, 2017

Area of Science:

Environmental Health
Toxicology
Chemical Engineering

Background:

Limited characterization of typical aerosol properties from electronic cigarettes (e-cigs).
Prior studies focused on toxic effects of e-cig components, not aerosol generation variability.
Understanding aerosol properties is crucial for accurate exposure assessment in toxicological studies.

Purpose of the Study:

To characterize the variability in mass concentration and particle size distribution of e-cigarette aerosols.
To investigate how different e-cig devices and e-liquid compositions affect aerosol properties.
To identify factors contributing to inconsistency in e-cig aerosol generation for research.

Main Methods:

Experimental setup designed to generate and measure e-cigarette aerosols.
Characterization of aerosol mass concentration and particle size distribution.
Comparison of aerosol properties across different e-cig devices and e-liquid formulations.

Main Results:

Significant inter-day variability observed in aerosol generation experiments.
Variability likely attributed to inconsistent quality control in electronic cigarette devices.
Particle size distribution and mass concentration showed considerable differences based on device and liquid.

Conclusions:

Electronic cigarette aerosol properties are highly variable, impacting experimental reproducibility.
A need exists for standardized protocols in generating and measuring e-cig aerosols for in vitro and in vivo studies.
Improved understanding of factors influencing e-cig aerosol generation is essential for reliable toxicological assessments.