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Pharmacokinetic models are mathematical constructs that represent and predict the time course of drug concentrations in the body, providing meaningful pharmacokinetic parameters. These models are categorized into compartment, physiological, and distributed parameter models.
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    Area of Science:

    • Machine Learning
    • Artificial Intelligence
    • Data Science

    Background:

    • Deep learning models, despite successes, suffer from interpretability issues, large data needs, complex tuning, and high computational costs.
    • These limitations hinder the practical application of advanced neural network-based deep models.

    Purpose of the Study:

    • To propose a new concept, the lightweight deep model (LDM), designed to mitigate the deficiencies of traditional deep learning.
    • To introduce and validate a deep partial least squares (DPLS) model as an instance of LDM.
    • To generalize DPLS into a more flexible form (GDPLS) with nonlinear mapping.

    Main Methods:

    • Constructed a deep partial least squares (DPLS) model, exploring LDM from a new perspective.
    • Theoretically proved the feasibility and advantages of DPLS.
    • Generalized DPLS to GDPLS by incorporating a nonlinear mapping layer between cascaded PLS layers.

    Main Results:

    • DPLS and GDPLS demonstrated competitive performance against existing deep models in regression and classification tasks.
    • The proposed models offer enhanced interpretability and efficiency compared to traditional deep learning methods.
    • The study provides clear insights into how the models improve performance and generate accurate results.

    Conclusions:

    • LDM, exemplified by DPLS and GDPLS, offers a viable, interpretable, and efficient alternative to fully connected neural networks.
    • These models address key limitations of deep learning, paving the way for broader practical applications.
    • While not replacing advanced deep vision or language models, LDM provides a valuable alternative for specific use cases.