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Related Concept Videos

Renewal of Intestinal Stem Cells01:23

Renewal of Intestinal Stem Cells

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The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the...
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Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
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Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

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Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
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Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal01:22

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Erythropoietin-producing hepatocellular carcinoma receptor (Eph) and its ligand, Eph receptor-interacting protein (Ephrin) were first discovered in the human carcinoma cell line, hence the name. Ephrin-Eph interaction guides cells to reach their appropriate location in adult tissues. They also play an essential role in the immune system by helping in immune cell migration, adhesion, and activation. Based on their structure and function, Eph is divided into two classes — EphA and EphB.
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Multipotency and Niche of Bulge Stem Cell01:06

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A hair follicle or HF is a small part of the skin that produces the hair shaft. Paul Gerson Unna was the first to observe a bulge in the human hair follicle's outer root sheath (ORS). The bulge is present between the sebaceous gland and the arrector pili muscle and is the niche for hair follicle stem cells (HFSCs). The bulge is also a niche for melanocyte stem cells, and their loss results in graying of hair. The HFSCs express Sox9 and Lhx2, which help them maintain stemness and prevent...
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Stem Cell Niche01:26

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The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
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Related Experiment Video

Updated: Sep 30, 2025

Isolating Intestinal Stem Cells from Adult Drosophila Midguts by FACS to Study Stem Cell Behavior During Aging
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Aging of intestinal stem cells.

Kodandaramireddy Nalapareddy1, Yi Zheng1, Hartmut Geiger2

  • 1Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center and University of Cincinnati, OH 45229, USA.

Stem Cell Reports
|March 11, 2022
PubMed
Summary
This summary is machine-generated.

Aging impairs intestinal stem cell function, affecting tissue regeneration. This review explores intrinsic aging mechanisms, extrinsic factors like the niche and microbiota, and strategies to rejuvenate these vital cells.

Keywords:
Cdc42 activityWntagingintestinal stem cells

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Area of Science:

  • Gastroenterology
  • Stem Cell Biology
  • Aging Research

Background:

  • Intestinal homeostasis relies on stem cell function.
  • Aging alters intestinal architecture and reduces regenerative capacity.
  • Decline in intestinal stem cell function is a key aspect of aging.

Purpose of the Study:

  • To review intrinsic mechanisms of intestinal stem cell aging.
  • To explore the role of extrinsic factors (niche, microbiota) in aging.
  • To present strategies for attenuating or reverting stem cell aging.

Main Methods:

  • Literature review of recent findings on intestinal stem cell aging.
  • Analysis of stem cell-intrinsic and extrinsic aging mechanisms.
  • Summary of emerging approaches for stem cell rejuvenation.

Main Results:

  • Aging impacts intestinal stem cell function through intrinsic pathways.
  • Extrinsic factors, including the niche microenvironment and microbiota, significantly influence stem cell aging.
  • Recent research identifies potential interventions to restore youthful stem cell function.

Conclusions:

  • Understanding intestinal stem cell aging is crucial for maintaining gut health.
  • Both intrinsic cellular changes and extrinsic environmental factors contribute to stem cell aging.
  • Targeting these mechanisms offers promise for therapeutic interventions in aging-related intestinal decline.