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Determining the level of essential elements in patients with Ewing Sarcoma: A correlation
Ghulam Qadir Chanihoon1, Zunera Khalid2, Hassan Imran Afridi1
1National Center of Excellence in Analytical Chemistry, University of Sindh, Jamshoro, 76090, Pakistan.
Environmental Research
|March 11, 2022
Summary
Ewing Sarcoma (ES) hypertension is linked to altered mineral metabolism. Patients showed higher sodium and lower magnesium, potassium, and calcium levels in biological samples compared to controls.
Area of Science:
- Biochemistry
- Oncology
- Nutritional Science
Background:
- Aberrant metal ion metabolism is crucial in health and disease.
- Ewing Sarcoma (ES) is a rare bone cancer, and its association with hypertension and mineral imbalances requires further investigation.
Purpose of the Study:
- To compare critical mineral levels (magnesium, sodium, calcium, potassium) in biological samples of patients with Ewing Sarcoma (ES) and hypertension versus nonhypertensive controls.
- To investigate the potential role of mineral deficiencies as risk factors in ES hypertension.
Main Methods:
- Elemental concentrations in scalp hair, blood, and serum were determined using atomic absorption spectrophotometry.
- Microwave-induced acid digestion was employed for sample preparation, with validation through wet acid digestion and reference materials.
Main Results:
- Patients with ES hypertension exhibited significantly higher sodium levels.
- Lower levels of magnesium, potassium, and calcium were observed in the scalp hair and blood of ES hypertension patients compared to controls.
Conclusions:
- Deficiencies in calcium, magnesium, and potassium may contribute to ES hypertension risk.
- Findings aid healthcare professionals in identifying essential micronutrient depletion in hypertensive patients with ES.
