Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Applicability boundaries and method-selection strategies for the CMC determination of pharmaceutical surfactants.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V·2026
Same author

Long-term endurance exercise influences exercise capacity in mice through modulation of the intestinal microbiota by fecal microbiota transplantation.

Frontiers in microbiology·2026
Same author

Enhancing Birefringence of Sulphates by Polarity Modification in Planar Cations.

Small (Weinheim an der Bergstrasse, Germany)·2026
Same author

Deep-Penetrating Transdermal Lipopeptide Liposomes for Sustained IL-17 Inhibition and Prevention of Psoriatic Recurrence.

Journal of the American Chemical Society·2026
Same author

Phenotypic and genotypic diversity in patients with Chinese aggrecan gene-related short stature.

Pediatric research·2026
Same author

Supramolecular self-assemblies of H6/doxorubicin reverse P-gp-mediated multidrug resistance in breast cancer.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V·2026

Related Experiment Video

Updated: Sep 30, 2025

Gold Nanorod-assisted Optical Stimulation of Neuronal Cells
09:31

Gold Nanorod-assisted Optical Stimulation of Neuronal Cells

Published on: April 27, 2015

9.1K

A triple enhanced permeable gold nanoraspberry designed for positive feedback interventional therapy.

Yanyan Liu1, Zixuan Ye1, Wenqian Yang1

  • 1Department of Pharmaceutics, State Key Laboratory of Nature Medicines, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, China.

Journal of Controlled Release : Official Journal of the Controlled Release Society
|March 11, 2022
PubMed
Summary

This study developed gold nanoraspberries (GNRs) that enhance drug delivery into tumors. These GNRs improve penetration and therapeutic efficacy for Her-2+ breast cancer treatment.

Keywords:
Dual responsiveGold nanoraspberriesInterventional therapyMultimode imagingPositive feedbackTriple enhanced permeation

More Related Videos

Preparation and Photoacoustic Analysis of Cellular Vehicles Containing Gold Nanorods
10:46

Preparation and Photoacoustic Analysis of Cellular Vehicles Containing Gold Nanorods

Published on: May 2, 2016

7.0K
Protocols for Assessing Radiofrequency Interactions with Gold Nanoparticles and Biological Systems for Non-invasive Hyperthermia Cancer Therapy
10:51

Protocols for Assessing Radiofrequency Interactions with Gold Nanoparticles and Biological Systems for Non-invasive Hyperthermia Cancer Therapy

Published on: August 28, 2013

11.0K

Related Experiment Videos

Last Updated: Sep 30, 2025

Gold Nanorod-assisted Optical Stimulation of Neuronal Cells
09:31

Gold Nanorod-assisted Optical Stimulation of Neuronal Cells

Published on: April 27, 2015

9.1K
Preparation and Photoacoustic Analysis of Cellular Vehicles Containing Gold Nanorods
10:46

Preparation and Photoacoustic Analysis of Cellular Vehicles Containing Gold Nanorods

Published on: May 2, 2016

7.0K
Protocols for Assessing Radiofrequency Interactions with Gold Nanoparticles and Biological Systems for Non-invasive Hyperthermia Cancer Therapy
10:51

Protocols for Assessing Radiofrequency Interactions with Gold Nanoparticles and Biological Systems for Non-invasive Hyperthermia Cancer Therapy

Published on: August 28, 2013

11.0K

Area of Science:

  • Nanomedicine
  • Biomaterials Engineering
  • Oncology

Background:

  • Tumor microenvironments impede nanoparticle penetration, limiting nanomedicine efficacy.
  • Developing strategies to enhance nanoparticle deep-tumor penetration is crucial for improved cancer therapy.

Purpose of the Study:

  • To construct gold nanoraspberries (GNRs) for enhanced deep-tumor penetration and therapeutic efficacy in Her-2+ breast cancer.
  • To investigate a triple-enhanced penetration platform leveraging photothermal effects, MMP-2/9 sensitivity, and fibroblast modulation.

Main Methods:

  • Synthesized GNRs using ultrasmall gold nanospheres (UGNPs) cross-linked with MMP-2/9-sensitive peptides.
  • Modified GNRs with trastuzumab (TRA) for Her-2 targeting and mertansine derivatives (DM1) for drug delivery.
  • Utilized near-infrared light for photothermal conversion, MMPs for GNR disintegration, and fibroblast modulation for enhanced penetration in a mouse model.

Main Results:

  • The GNR platform demonstrated a triple-enhanced penetration mechanism, significantly increasing nanoparticle accumulation within tumors.
  • Near-infrared light triggered photothermal effects, increasing vascular permeability for initial nanoparticle entry.
  • MMP-2/9 triggered GNR disintegration into smaller UGNPs, facilitating deeper diffusion, while UGNPs also modulated cancer-associated fibroblasts to aid penetration.
  • This created a positive feedback loop, amplifying photothermal effects and in vivo permeability.
  • The GNRs exhibited excellent imaging capabilities (CT, photoacoustic, photothermal) and high anti-tumor efficacy.

Conclusions:

  • MMP-2/redox dual-responsive GNRs represent a promising drug delivery system for Her-2+ breast cancer.
  • The triple enhanced penetration platform significantly improves therapeutic outcomes by overcoming tumor penetration barriers.