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Related Experiment Videos

High-level trimethoprim resistance in urinary bacteria.

S G Amyes, C J Doherty, H K Young

    European Journal of Clinical Microbiology
    |June 1, 1986
    PubMed
    Summary

    Trimethoprim resistance in significant bacteriuria pathogens increased in men and elderly patients but decreased overall annually. Trimethoprim resistance genes are migrating to bacterial chromosomes.

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    Area of Science:

    • Medical Microbiology
    • Antimicrobial Resistance
    • Infectious Diseases

    Background:

    • Trimethoprim is a widely used antibiotic for treating bacterial infections.
    • Bacteriuria, particularly significant bacteriuria, can lead to serious health complications.
    • Monitoring antimicrobial resistance patterns is crucial for effective treatment strategies.

    Purpose of the Study:

    • To evaluate the incidence and types of trimethoprim resistance in pathogens causing significant bacteriuria.
    • To compare current trimethoprim resistance trends with previous findings.
    • To investigate the mechanisms of trimethoprim resistance transfer and chromosomal integration.

    Main Methods:

    • A three-year evaluation of trimethoprim resistance in bacterial pathogens from patients with significant bacteriuria.
    • Comparison of resistance data with a historical study.
    • Analysis of trimethoprim resistance transferability and transposon movement.

    Main Results:

    • Trimethoprim resistance was 50% more frequent in men and nearly twice as frequent in elderly patients.
    • The overall proportion of trimethoprim-resistant strains decreased annually.
    • Transferable trimethoprim resistance halved, with evidence of transposon movement to the bacterial chromosome.

    Conclusions:

    • Despite increased resistance in specific demographics, overall trimethoprim resistance is declining.
    • The findings suggest the migration of high-level trimethoprim resistance genes to the bacterial chromosome.
    • Continued surveillance of antimicrobial resistance is essential for public health.

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