Related Experiment Video

Updated: Sep 30, 2025

Engineering Oncogenic Heterozygous Gain-of-Function Mutations in Human Hematopoietic Stem and Progenitor Cells
12:04

Engineering Oncogenic Heterozygous Gain-of-Function Mutations in Human Hematopoietic Stem and Progenitor Cells

Published on: March 10, 2023

3.8K

Genome editing via non-viral delivery platforms: current progress in personalized cancer therapy

Tianxia Lan1, Haiying Que1, Min Luo1

  • 1Laboratory of Aging Research and Cancer Drug Target, State Key Laboratory of Biotherapy, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, No. 17, Block 3, Southern Renmin Road, Sichuan, 610041, Chengdu, China.

Molecular Cancer
|March 12, 2022
PubMed

Insights

Personalized cancer therapies utilize genome editing tools (GETs) for precise treatment. Non-viral delivery systems enhance the safety and efficacy of these advanced anti-cancer strategies.

Area of Science:

  • Oncology
  • Genetics
  • Biotechnology

Background:

  • Cancer remains a leading global health threat despite extensive research into therapeutics.
  • Rising cancer incidence and mortality highlight the need for innovative treatment approaches.
  • Personalized anti-cancer therapies offer a targeted strategy based on genomic analysis.

Purpose of the Study:

  • To review recent advancements in genome editing tools (GETs) for cancer treatment.
  • To assess the integration of non-viral delivery systems with GETs for personalized cancer therapy.
  • To discuss the potential of combining GETs and non-viral delivery for future clinical applications.

Main Methods:

  • Review of current literature on genome editing technologies in cancer research.
  • Analysis of studies investigating non-viral delivery systems for therapeutic applications.
  • Evaluation of laboratory and clinical investigations on GETs combined with delivery systems.

Main Results:

  • Genome editing enables direct modification of cancer-promoting genes and development of personalized immune cells.
  • Non-viral delivery systems show promise for safe and effective transport of GETs into cancer cells.
  • Emerging research supports the combination of GETs and non-viral delivery for personalized cancer treatment.

Conclusions:

  • Genome editing represents a powerful approach for developing personalized anti-cancer therapies.
  • Non-viral delivery systems are crucial for the safe and efficient clinical translation of GETs.
  • The synergy between GETs and non-viral delivery systems holds significant potential for advancing cancer treatment.
Keywords:
Genome editing toolNon-viral delivery systemPersonalized anti-cancer therapy

More Related Videos

Somatic Genome-Engineered Mouse Models Using In Vivo Microinjection and Electroporation08:06

Somatic Genome-Engineered Mouse Models Using In Vivo Microinjection and Electroporation

Published on: May 5, 2023

1.9K
Non-Viral Engineering of Primary Human T Cells via Homology-Mediated End-Joining Targeted Integration of Large DNA Templates06:10

Non-Viral Engineering of Primary Human T Cells via Homology-Mediated End-Joining Targeted Integration of Large DNA Templates

Published on: May 9, 2025

473

Related Concept Videos

Gene Therapy00:59

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
26.0K
CRISPR01:59

CRISPR

Genome editing technologies allow scientists to modify an organism’s DNA via the addition, removal, or rearrangement of genetic material at specific genomic locations. These types of techniques could potentially be used to cure genetic disorders such as hemophilia and sickle cell anemia. One popular and widely used DNA-editing research tool that could lead to safe and effective cures for genetic disorders is the CRISPR-Cas9 system. CRISPR-Cas9 stands for Clustered Regularly Interspaced...
53.2K
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.1K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.9K
In-vitro Mutagenesis01:16

In-vitro Mutagenesis

To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.
14.7K
What is Genetic Engineering?00:49

What is Genetic Engineering?

Overview
75.9K