Related Experiment Video

Updated: Sep 30, 2025

Creation of Patient-Specific Silicone Cardiac Models with Applications in Pre-surgical Plans and Hands-on Training
09:15

Creation of Patient-Specific Silicone Cardiac Models with Applications in Pre-surgical Plans and Hands-on Training

Published on: February 10, 2022

3.7K

Being born with a single cardiac ventricle: What do we tell prospective parents

Yves d'Udekem1, Darren Hutchinson2

  • 1Division of Cardiac Surgery, Children's National Hospital and Children's National Heart Institute, Washington, District of Columbia, USA.

Prenatal Diagnosis
|March 12, 2022
PubMed

Insights

Single ventricle cardiac disease, a severe congenital heart defect, now allows longer survival into adulthood. This review covers diagnosis, treatment, outcomes, and future care for patients with single ventricle hearts.

Area of Science:

  • Cardiology
  • Pediatric Cardiology
  • Congenital Heart Disease

Background:

  • Single ventricle cardiac disease is a severe congenital heart defect characterized by a single ventricular cavity.
  • While historically associated with poor prognosis, current medical techniques have significantly improved survival rates, with many patients now living into adulthood.

Purpose of the Study:

  • To provide an up-to-date review of single ventricle cardiac disease.
  • To discuss prenatal assessment, treatment pathways, and short- and long-term outcomes.
  • To offer a contemporary perspective on patient and family counseling.

Main Methods:

  • Comprehensive literature review of single ventricle cardiac disease.
  • Synthesis of information on diagnosis, treatment, and outcomes.
  • Analysis of current approaches to patient and family counseling.

Main Results:

  • Patients with single ventricle defects demonstrate improved long-term survival into adulthood.
  • A significant burden of disease persists for many adult survivors.
  • Updated information is crucial for effective prenatal and lifelong care planning.

Conclusions:

  • Improved survival necessitates a contemporary approach to managing single ventricle cardiac disease.
  • Effective counseling, starting from prenatal diagnosis, is vital for families.
  • Ongoing research and multidisciplinary care are essential for optimizing outcomes.

More Related Videos

A Pipeline to Characterize Structural Heart Defects in the Fetal Mouse08:19

A Pipeline to Characterize Structural Heart Defects in the Fetal Mouse

Published on: December 16, 2022

2.0K
Murine Fetal Echocardiography08:04

Murine Fetal Echocardiography

Published on: February 15, 2013

17.5K

Related Concept Videos

Development of the Heart01:27

Development of the Heart

The development of the human heart, a crucial organ, commences from the mesoderm on the 18th or 19th day after fertilization. This process initiates in the cardiogenic area, a group of mesodermal cells at the embryo's head end, which evolves into elongated strands known as cardiogenic cords. These cords undergo a transformation to form hollow-centered endocardial tubes.
As the embryo undergoes lateral folding, these paired tubes approach each other, merging into a single primitive heart...
1.3K
Chambers of the Heart01:16

Chambers of the Heart

The human heart is a complex organ made up of four chambers: the right and left atria and the right and left ventricles. These internal chambers are separated by partitions known as the interatrial and interventricular septa. The exterior of the heart features a groove known as the coronary sulcus that demarcates the atria from the ventricles, while the anterior and posterior interventricular sulci distinguish between the two ventricles.
Deoxygenated blood from the body is received in the right...
6.2K
Fetal Circulation01:14

Fetal Circulation

Fetal circulation is a unique system that facilitates the exchange of gases, nutrients, and waste products between the developing fetus and the mother. This intricate process takes place through a special organ called the placenta.
Two umbilical arteries transport blood from the fetus to the placenta. At the placenta, the blood absorbs oxygen and nutrients while simultaneously eliminating waste products. This oxygen-enriched and nutrient-rich blood then returns to the fetus through one...
1.5K
Anatomy of the Heart01:27

Anatomy of the Heart

The human heart is made up of three layers of tissue that are surrounded by the pericardium, a membrane that protects and confines the heart. The outermost layer, closest to the pericardium, is the epicardium. The pericardial cavity separates the pericardium from the epicardium. Beneath the epicardium is the myocardium, the middle layer, and the endocardium, the innermost layer. There are four chambers of the heart: the right atrium, the right ventricle, the left atrium, and the left ventricle.
111.9K
Heart Valves01:16

Heart Valves

The human heart is a complex organ with an intricate system of valves that regulate blood flow. There are two main types of valves: atrioventricular (AV) valves and semilunar valves.
The AV valves prevent the backflow of blood from the ventricles to the atria during ventricular contraction. These valves function with the assistance of the chordae tendineae and papillary muscles. When the ventricles are relaxed, the chordae tendineae are slack, allowing blood to flow from the atria into the...
6.4K
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
78