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Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation
Published on: July 20, 2022
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Disentangling the association between kidney function and atrial fibrillation: a bidirectional Mendelian
Sven Geurts1, Anna C van der Burgh2, Maxime M Bos1
1Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
International Journal of Cardiology
|March 12, 2022
Summary
This study found a two-way causal link between kidney disease and atrial fibrillation (AF). Shared genetics may offer therapeutic targets for preventing both conditions.
Area of Science:
- Cardiovascular Medicine
- Nephrology
- Genetic Epidemiology
Background:
- The causal relationship between kidney function and atrial fibrillation (AF) is not fully understood.
- Bidirectional associations require investigation to clarify disease pathways.
Purpose of the Study:
- To investigate the bidirectional causal association between kidney function and AF using Mendelian randomization.
- To identify potential shared genetic factors influencing both conditions.
Main Methods:
- A bidirectional two-sample Mendelian randomization (MR) analysis was performed.
- Genetic variants associated with kidney function (eGFRcreat, BUN, CKD, eGFRcys, UACR, microalbuminuria) and AF were utilized from large genome-wide association studies (GWAS).
- Inverse-variance weighted (IVW) method and sensitivity analyses were employed.
Main Results:
- Evidence supported a causal effect of chronic kidney disease (CKD) and microalbuminuria on AF risk.
- Atrial fibrillation (AF) showed a causal effect on estimated glomerular filtration rate (eGFRcreat), CKD, and microalbuminuria, with a suggestive effect on eGFRcys.
- Sensitivity analyses confirmed the robustness of these findings.
Conclusions:
- A bidirectional causal association between kidney function and AF was supported.
- The shared genetic architecture between kidney dysfunction and AF suggests potential therapeutic targets for prevention.
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