Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Role of Hippocampus in Memory

Role of Hippocampus in Memory

The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Anxiety, stress, and affective modulation on object-location memory: A systematic review in virtual environments.

Cognitive, affective & behavioral neuroscience·2026

Same author

Frequency-specific photobiomodulation at theta and gamma enhances cognitive networks and mitigates age-related decline.

GeroScience·2026

Same author

Sex differences in the use of spatial strategies in humans: An updated systematic review of the last decade.

Behavioural brain research·2026

Same author

Early vs Delayed Extubation After Thrombectomy for Acute Ischemic Stroke: The EDESTROKE Randomized Clinical Trial.

JAMA neurology·2026

Same author

Effects of transcranial photobiomodulation on anxiety-like behavior and spatial learning in adult and old female rats.

Physiology & behavior·2026

Same author

Videolaryngoscopy for awake tracheal intubation in patients with anticipated difficult airways: a prospective multicentre cohort study.

Anaesthesia, critical care & pain medicine·2026

Search research articles

Related Experiment Video

Updated: Sep 30, 2025

The Double-H Maze: A Robust Behavioral Test for Learning and Memory in Rodents

The Double-H Maze: A Robust Behavioral Test for Learning and Memory in Rodents

Published on: July 8, 2015

Functional neuroanatomy of allocentric remote spatial memory in rodents.

Candela Zorzo¹, Jorge L Arias¹, Marta Méndez¹

¹Department of Psychology, University of Oviedo, Faculty of Psychology, Plaza Feijoo s/n, 33003 Oviedo, Asturias, Spain; Neuroscience Institute of Principado de Asturias (INEUROPA).

Neuroscience and Biobehavioral Reviews

|March 12, 2022

Summary

This review on spatial memory retrieval in rodents shows that forgetting occurs normally after one month. Brain changes in the neocortex and hippocampus are linked to recalling spatial memories.

Keywords:

Allocentric strategy Remote memory Retrieval Rodents System consolidation

More Related Videos

An Appetitive Spatial Working Memory Task for Mice in a Semi-Automated 8-Arm Radial Maze, Reducing Fearful Memory Association in the Maze

An Appetitive Spatial Working Memory Task for Mice in a Semi-Automated 8-Arm Radial Maze, Reducing Fearful Memory Association in the Maze

Published on: July 29, 2025

A Within-Subject Experimental Design using an Object Location Task in Rats

A Within-Subject Experimental Design using an Object Location Task in Rats

Published on: May 6, 2021

Related Experiment Videos

Last Updated: Sep 30, 2025

The Double-H Maze: A Robust Behavioral Test for Learning and Memory in Rodents

The Double-H Maze: A Robust Behavioral Test for Learning and Memory in Rodents

Published on: July 8, 2015

An Appetitive Spatial Working Memory Task for Mice in a Semi-Automated 8-Arm Radial Maze, Reducing Fearful Memory Association in the Maze

An Appetitive Spatial Working Memory Task for Mice in a Semi-Automated 8-Arm Radial Maze, Reducing Fearful Memory Association in the Maze

Published on: July 29, 2025

A Within-Subject Experimental Design using an Object Location Task in Rats

A Within-Subject Experimental Design using an Object Location Task in Rats

Published on: May 6, 2021

Area of Science:

Neuroscience
Cognitive Science
Memory Research

Background:

Spatial cognition relies on learning, consolidation, storage, and retrieval of spatial memory traces.
The exact roles and interactions of brain regions during remote spatial memory retrieval remain unclear.

Purpose of the Study:

To systematically review studies on allocentric remote spatial retrieval in rodents, assessed at least two weeks post-acquisition.
To identify brain areas and their functional contributions during the retrieval of past spatial events.

Main Methods:

Systematic review of rodent studies involving non-invasive interventions, brain lesions, inactivation, pharmacological treatments, chemical agents, and genetic manipulations.
Focus on allocentric remote spatial retrieval at least two weeks after memory acquisition.

Main Results:

Normal forgetting patterns were observed when time intervals approached or exceeded one month.
Morphological and functional changes in neocortical areas, hippocampus, and thalamus were associated with spatial memory retrieval.
Increased neocortical involvement in remote spatial retrieval was noted.

Conclusions:

The hippocampus appears crucial for retrieving fine spatial details during remote recall.
Neocortical areas show increasing recruitment for remote spatial memory retrieval.
Understanding these brain mechanisms aids in comprehending memory maintenance timing and normal forgetting processes.