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Updated: Sep 30, 2025

Deacetylation Assays to Unravel the Interplay between Sirtuins SIRT2 and Specific Protein-substrates
Published on: February 27, 2016
SIRT6 serves as a polyhedron in glycolytic metabolism and ageing-related diseases
Zhixiao Yuan1, Yutian Zeng1, Yao Tian1
1Institute of Animal Genetics and Breeding, Sichuan Agricultural University, Chengdu 611130, Sichuan, China.
Abstract:
Sirtuin 6 (SIRT6) is a nicotinamide adenine dinucleotide (NAD+)-dependent enzyme. It is a novel member of the sirtuin family that has been shown to have an important role in various molecular pathways in glycolysis, cancer, and neurodegenerative responses. Recently, SIRT6 has emerged as a prominent research issue because its biochemical activity and regulation are possibly associated with human metabolism and disease. In this review, we summarized the connection between SIRT6 and glycolytic metabolism; discussed recent developments in the involvement of SIRT6 in a variety of life-threatening illnesses, including cancer, neurodegenerative diseases and cardiovascular disease; and explored possible treatment approaches for those diseases with SIRT6. This review provides insights into the role of SIRT6 in disease.
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