Related Experiment Video
Updated: Sep 30, 2025

Author Spotlight: Asymmetric Field Flow Fractionation for Bioreactor Integration
Published on: February 2, 2024
Isolation, synthesis, identification of new process-related impurities in evocalcet
Hongyi Yan1, Yabo Wang1, Yongli Yue1
1Department of Medicinal Chemistry, Hebei Medical University, 361 Zhongshan East Road, Shijiazhuang 050017, China.
Abstract:
Evocalcet is a calcimimetic for the treatment of secondary hyperparathyroidism. In the preparation of evocalcet, eleven process-related impurities were detected in the reaction solution of the last step at levels of 0.05%- 2.50% by a new HPLC method. Ten impurities were separated from the enriched mother liquor and synthesized directly. These impurities were characterized and identified by HRMS and NMR spectra and then coinjected with commercial products to confirm their retention times in HPLC. The possible formation pathways and synthetic methods of ten process-related impurities ware discussed in detail.
More Related Videos
11:14Two-way Valorization of Blast Furnace Slag: Synthesis of Precipitated Calcium Carbonate and Zeolitic Heavy Metal Adsorbent
Published on: February 21, 2017
09:56Scalable Isolation and Purification of Extracellular Vesicles from Escherichia coli and Other Bacteria
Published on: October 13, 2021
Related Concept Videos
Washing, Drying, and Ignition of Precipitates
Qualitative Analysis
For instance, group IV...
Precipitation Processes
Volatilization
Precipitation and Co-precipitation