Related Experiment Video
Updated: Sep 30, 2025
09:36
Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device
Published on: September 24, 2020
2.9K
Renal function during sevoflurane or total intravenous propofol anaesthesia: a single-centre parallel randomised
Stephanie Franzén1, Egidijus Semenas1, Micael Taavo1
1Department of Surgical Sciences, Anaesthesiology and Intensive Care, Uppsala University, Uppsala, Sweden.
British Journal of Anaesthesia
|March 13, 2022
Summary
Sevoflurane anesthesia reduced urine output and sodium excretion compared to propofol. Sevoflurane also increased plasma renin and postoperative creatinine levels, suggesting potential renal impacts.
Area of Science:
- Anesthesiology
- Nephrology
- Surgical Care
Background:
- Anesthetic choice can affect renal perfusion and function.
- Investigating the impact of propofol versus sevoflurane on kidney function is crucial for patient safety.
Purpose of the Study:
- To compare renal function in patients undergoing spinal surgery under propofol versus sevoflurane anesthesia.
- To evaluate the effects of these anesthetics on urine output, electrolyte excretion, and renal biomarkers.
Main Methods:
- Randomized controlled trial in 27 patients (ASA physical status 1-2) undergoing spinal surgery.
- Collected blood and urine samples at multiple time points: pre-anesthesia, during anesthesia, post-operative care, and the day after surgery.
- Measured urine output, sodium, potassium excretion, plasma renin, arginine-vasopressin, and creatinine.
Main Results:
- Sevoflurane anesthesia led to significantly lower urine output and sodium excretion compared to propofol.
- Sevoflurane increased plasma renin levels and postoperative plasma creatinine compared to propofol.
- Urinary potassium excretion was lower during anesthesia than postoperatively, irrespective of the anesthetic agent.
Conclusions:
- Sevoflurane anesthesia impairs renal function by reducing urine output and sodium excretion, and increasing plasma renin and creatinine.
- Further research is needed to understand the clinical implications for acute kidney injury and fluid management during surgery.
More Related Videos
03:02Application of Dixon's Up-and-Down Design to Estimate the Minimum Alveolar Concentration of Sevoflurane in Rats with Refined Movement Classification
Published on: July 25, 2025
158
04:56In Vitro Method to Control Concentrations of Halogenated Gases in Cultured Alveolar Epithelial Cells
Published on: October 23, 2018
6.7K
Related Concept Videos
01:24Parenteral Anesthetics: Overview
221
Intravenous anesthetics are drugs administered parenterally to induce anesthesia or sedation. Propofol is a widely used agent formulated as a 1% emulsion in soybean oil, glycerol, and egg phosphatide. It induces rapid anesthesia primarily due to its rapid distribution from the bloodstream to target tissues and is metabolized in the liver. However, it can cause significant pain on injection and hypertriglyceridemia. Fospropofol, a water-based prodrug of propofol, lacks these adverse effects.
221
01:24General Anesthesia: Overview
311
Anesthesia is a medical procedure that uses drugs for CNS suppression to enable painless surgeries and procedures. The selection of anesthetics is influenced by their pharmacokinetic properties, side effects, and patient characteristics. Various types of anesthesia include general, local, regional, spinal, and inhalational.
General anesthesia induces unconsciousness in the whole body, while the others target specific areas or sensations. It is administered to minimize adverse effects, maintain...
General anesthesia induces unconsciousness in the whole body, while the others target specific areas or sensations. It is administered to minimize adverse effects, maintain...
311
01:20Inhalational Anesthetics: Overview
557
Inhalation anesthetics are drugs that induce general anesthesia upon inhalation. They work by increasing the sensitivity of GABAA receptors or inhibiting NMDA receptors, leading to a decrease in central nervous system activity. The depth of anesthesia can be rapidly adjusted by changing the concentration of the inhaled gas. Some common examples of inhalational anesthetics include volatile liquids like isoflurane, desflurane, sevoflurane and gases like xenon and nitrous oxide. Isoflurane, a...
557
01:22Stages of General Anesthesia
797
Various sedation levels offer significant advantages in facilitating procedural interventions for patients undergoing medical or invasive surgical procedures. These levels span from anxiolysis to general anesthesia, providing a spectrum of sedative effects to cater to specific patient needs. Anxiolysis reduces anxiety and is achieved through minimal sedation, enabling patients to remain awake and responsive while feeling more at ease during the procedure. This level can benefit minor...
797
01:24Serum Studies: Renal Function Tests
88
Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.
88
01:30Acute Kidney Injury IV: Diagnostic Studies and Prevention
69
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
69