Related Experiment Video
Updated: Sep 30, 2025
14:37
High-throughput Synthesis of Carbohydrates and Functionalization of Polyanhydride Nanoparticles
Published on: July 6, 2012
11.6K
Carboxy-functionalized pH responsive capsule polymer particles fabricated by particulate interfacial
Yukiya Kitayama1, Atsushi Harada1
1Department of Applied Chemistry, Graduate School of Engineering, Osaka Prefecture University, 1-1, Gakuen-cho, Naka-ku, Sakai, Osaka 599-8531, Japan. kitayama@chem.osakafu-u.ac.jp.
Journal of Materials Chemistry. B
|March 13, 2022
Summary
New carboxy-functionalized capsule polymer particles exhibit pH-responsive controlled release. These particles, fabricated using interfacial photocrosslinking, show stable retention in acidic conditions and release in neutral to alkaline environments.
Area of Science:
- Polymer Science
- Materials Science
- Nanotechnology
Background:
- pH-responsive capsule particles are crucial for applications like drug delivery and self-healing materials.
- Controlled release mechanisms are key to optimizing the performance of these advanced materials.
- Carboxy-functionalized polymers offer tunable properties for responsive systems.
Purpose of the Study:
- To fabricate novel carboxy-functionalized capsule polymer particles with neutral-alkaline pH-responsive controlled release capabilities.
- To develop a fabrication method using interfacial photocrosslinking for hollow polymer capsules.
- To demonstrate the controlled release of encapsulated substances based on pH changes.
Main Methods:
- Fabrication of spherical photoreactive polymer particles: poly(2-carboxyethyl acrylate-co-2-cinnamoylethyl methacrylate) [P(CEA-CEMA)].
- Particulate interfacial photocrosslinking to create shell-crosslinked hollow polymer particles.
- Encapsulation of sulforhodamine B as a model dye into the hollow particles.
Main Results:
- Successfully fabricated hollow polymer particles using the particulate interfacial photocrosslinking method.
- Demonstrated stable retention of encapsulated sulforhodamine B under acidic pH conditions.
- Achieved tunable, gradual to drastic release of sulforhodamine B under neutral to alkaline pH conditions, confirming pH-responsive controlled release.
Conclusions:
- The interfacial photocrosslinking technique is effective for creating carboxy-functionalized hollow and capsule polymer particles.
- The fabricated capsule particles exhibit significant pH-responsive controlled release properties in the neutral-alkaline range.
- These findings pave the way for advanced applications in drug delivery and responsive materials.
