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Related Experiment Video

Updated: Sep 30, 2025

A Protocol for Comprehensive Assessment of Bulbar Dysfunction in Amyotrophic Lateral Sclerosis ALS
12:43

A Protocol for Comprehensive Assessment of Bulbar Dysfunction in Amyotrophic Lateral Sclerosis ALS

Published on: February 21, 2011

35.0K

An Automated Tongue Tracker for Quantifying Bulbar Function in ALS.

Alicia Northall1, Budhaditya Mukhopadhyay1, Miriam Weber2

  • 1Institute for Cognitive Neurology and Dementia Research, Otto-von-Guericke University Magdeburg, Magdeburg, Germany.

Frontiers in Neurology
|March 14, 2022
PubMed
Summary
This summary is machine-generated.

A new open-source tool, Tongue Tracker (TT), quantifies bulbar function in neurological disorders like ALS. TT tracks tongue movements from videos, offering a new way to measure bulbar impairment and potentially aid diagnosis.

Keywords:
amyotrophic lateral sclerosisbulbarneural networkquantificationtongue

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Area of Science:

  • Neurology
  • Biomedical Engineering
  • Medical Technology

Background:

  • Bulbar symptoms (difficulty swallowing/speaking) are common in amyotrophic lateral sclerosis (ALS) and stroke.
  • These symptoms impact clinical outcomes, including survival time.
  • Quantitative methods for measuring bulbar function are lacking.

Purpose of the Study:

  • To develop an open-source tool for quantifying bulbar function.
  • To assess the utility of this tool in patients with ALS.

Main Methods:

  • Developed an open-source tool named Tongue Tracker (TT).
  • Trained a neural network to track kinematic tongue features from short video clips of lateral tongue movements.
  • Tested TT on 16 healthy controls and 10 patients with ALS (2 bulbar-onset, 8 limb-onset, 5 of whom had bulbar impairment).

Main Results:

  • Validated TT against manual delineation of tongue movements.
  • An early-stage bulbar-onset ALS patient exhibited fewer and slower tongue movements than controls.
  • Five bulbar-impaired limb-onset ALS patients showed distinct tongue kinematic profiles compared to healthy controls.

Conclusions:

  • Tongue Tracker (TT) can detect quantitative markers of bulbar dysfunction in ALS and other motor disorders.
  • TT may identify signatures of spasticity or muscle weakness affecting tongue movement speed and topography.
  • This tool offers a potential method for objective assessment of bulbar impairment.