Acacetin as a Potential Protective Compound against Cardiovascular Diseases
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Updated: Sep 30, 2025

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Published on: April 18, 2025
Chunxuan Wu1, Jianhua Yan1, Wei Li1
1Department of Cardiology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Abstract:
Acacetin (5,7-dihydroxy-4'-methoxyflavone) is the major bioactive component of the traditional Chinese medicine "Snow lotus". As a natural flavonoid compound, it has been shown to have good pharmacological effects such as anti-inflammatory, anticancer, and anti-obesity. Among them, its prominent role in cardiovascular diseases (CVD) has received extensive attention from scholars in recent years. In this review, the protective effects of acacetin on a variety of cardiovascular diseases, as well as the existing problems and prospects, are discussed and summarized. This review also highlights the great potential of acacetin, a natural-derived Chinese medicine, as a cardiovascular agent candidate.
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