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Updated: Sep 30, 2025

Imaging Amyloid Tissues Stained with Luminescent Conjugated Oligothiophenes by Hyperspectral Confocal Microscopy and Fluorescence Lifetime Imaging

Imaging Amyloid Tissues Stained with Luminescent Conjugated Oligothiophenes by Hyperspectral Confocal Microscopy and Fluorescence Lifetime Imaging

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Oral amyloidosis: A case report and diagnostic algorithm.

Sudip Indu¹, Indranil Deb Roy², Rohit Tewari³

¹Division of Oral Pathology, Army Dental Centre (R and R), New Delhi, India.

Journal of Oral and Maxillofacial Pathology : JOMFP

|March 14, 2022

Summary

This summary is machine-generated.

Oral amyloidosis, a rare condition of abnormal protein buildup, can present as an enlarged tongue. Early diagnosis is crucial for proper management and prognosis.

Keywords:

Amyloidosis Congo red stain and Immunohistochemistry Key Messages: Accurate and earlydiagnoses of diseases like Amyloidosis arekeyto successful management of patients suffering with these rare types of disorders. Clinicians and pathologists should be well versedwith varied symptoms that these lesions present with and the exhaustive panel of diagnostic tests which must be advised to arrive at a definite diagnosis.tongue

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Area of Science:

Medicine
Pathology

Background:

Amyloidosis involves abnormal protein aggregation in extracellular spaces, damaging organs.
Oral amyloidosis is rare, often affecting the tongue, and requires precise identification for effective treatment.

Observation:

An 84-year-old male presented with tongue enlargement, burning sensation, and facial papules.
Biopsy confirmed amyloid deposits using Congo red stain and Immunohistochemistry.

Findings:

The case highlights oral amyloidosis presenting as an isolated tongue enlargement.
Diagnostic confirmation relied on histopathological examination and specific staining techniques.

Implications:

Suspect oral amyloidosis with unexplained tongue enlargement.
Prompt investigation is vital to rule out systemic involvement and guide therapy.