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Dynamic Oscillations Evoked by Subcallosal Cingulate Deep Brain Stimulation.

Vineet Tiruvadi^1,2,3, Ki Sueng Choi⁴, Robert E Gross^1,2

¹Emory School of Medicine, Emory University, Atlanta, GA, United States.

Frontiers in Neuroscience

|March 14, 2022

Summary

This summary is machine-generated.

Researchers discovered novel dynamic oscillations (DOs) during deep brain stimulation (DBS) for depression. These neural signals, recorded via intracranial LFP, may offer insights into DBS mechanisms and guide future treatments.

Keywords:

DBS cingulate dynamics subcallosal tractography

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Area of Science:

Neuroscience
Neuromodulation
Psychiatry

Background:

Deep brain stimulation (DBS) of subcallosal cingulate white matter (SCCwm) is effective for depression.
The precise neural mechanisms underlying DBS efficacy remain largely unknown.

Purpose of the Study:

To investigate the brain dynamics associated with SCCwm DBS in patients with depression.
To identify novel neural signals that could explain DBS's therapeutic effects.

Main Methods:

Intracranial local field potentials (LFPs) were recorded in 6 patients undergoing SCCwm DBS.
Novel dynamic oscillations (DOs) were identified and characterized.
White matter tracts related to DOs were analyzed, with preliminary electroencephalography (dEEG) data also examined.

Main Results:

A novel neural signal, dynamic oscillations (DOs), was consistently evoked in LFP recordings during SCCwm DBS.
DOs exhibited significant inter-patient variability in frequency and dynamics.
DOs were associated with specific white matter tracts, suggesting network engagement.

Conclusions:

DOs represent a potentially objective neural signal linked to SCCwm DBS.
Further research into DOs can elucidate DBS mechanisms and inform connectomics-guided neuromodulation strategies.