Related Experiment Video

Updated: Sep 30, 2025

Author Spotlight: Studying the Impact of Maternal Dietary Deficiencies on Long-Term Offspring Health Outcomes
03:19

Author Spotlight: Studying the Impact of Maternal Dietary Deficiencies on Long-Term Offspring Health Outcomes

Published on: June 28, 2024

520

The Effects of Clofibrate on Neonatal Jaundice: A Systematic Review

Fathemeh Eghbalian1, Ali Hasanpour-Dehkordi2, Roya Raeisi1

  • 1Department of Pediatric, Hamadan University of Medical Sciences, Hamadan, Iran.

International Journal of Preventive Medicine
|March 14, 2022
PubMed

Insights

Clofibrate effectively treats neonatal jaundice by enhancing bilirubin excretion. Studies show a 25 mg/kg dosage reduces Total Serum Bilirubin (TSB) in infants without side effects, though long-term data is limited.

Area of Science:

  • Neonatal Medicine
  • Pharmacology
  • Biochemistry

Background:

  • Neonatal jaundice is a common condition with severe complications like kernicterus.
  • Clofibrate, an aryloxy isobutyric acid derivative, has shown potential in treating neonatal jaundice.

Purpose of the Study:

  • To investigate the effects of clofibrate on neonatal jaundice.
  • To elucidate the mechanism of action of clofibrate in neonatal jaundice treatment.

Main Methods:

  • A systematic literature search was conducted using keywords like "Clofibrate" and "Neonatal jaundice" across major databases (ISI, Scopus, PubMed, Google Scholar).
  • 24 relevant studies were included in this review.

Main Results:

  • Clofibrate facilitates bilirubin transfer to hepatocytes, hepatic uptake, storage, and conjugation (via UGT1A1) into bilirubin conjugates.
  • It promotes the excretion of bilirubin conjugates into bile via MRP2.
  • A dosage of 25 mg/kg clofibrate significantly reduced Total Serum Bilirubin (TSB) in infants without reported side effects.

Conclusions:

  • Clofibrate is effective in reducing TSB in neonates with short-term use.
  • A dosage of 25 mg/kg shows promise for full-term infants.
  • Further research is needed to evaluate the long-term effects of clofibrate in neonatal jaundice treatment.
Abstract

Keywords:
Clofibratehyperbilirubinemianeonatal jaundicenewborn jaundice

More Related Videos

Isolation of Neonatal Extrahepatic Cholangiocytes07:54

Isolation of Neonatal Extrahepatic Cholangiocytes

Published on: June 5, 2014

10.4K
How to Administer Near-Infrared Spectroscopy in Critically ill Neonates, Infants, and Children07:27

How to Administer Near-Infrared Spectroscopy in Critically ill Neonates, Infants, and Children

Published on: August 19, 2020

11.7K

Related Concept Videos

Teratogenicity01:07

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
2.9K
Hepatic Drug Excretion: Influencing Factors01:16

Hepatic Drug Excretion: Influencing Factors

The biliary system of the liver, crucial for bile secretion and drug excretion, comprises intrahepatic bile ducts that merge to form the common hepatic duct. This duct, carrying hepatic bile, combines with the cystic duct, draining the gallbladder and forming the common bile duct, which empties into the duodenum. Bile, produced by hepatic cells lining the bile canaliculi, is composed primarily of water, bile salts, pigments, electrolytes, and lesser amounts of cholesterol and fatty acids. Bile...
256
Hepatic Drug Clearance: Effect of Protein Binding01:09

Hepatic Drug Clearance: Effect of Protein Binding

Hepatic clearance is influenced by protein binding based on the drug's extraction ratio. Drugs with high extraction ratios are considered flow-limited and remain unaffected by protein binding during hepatic clearance. On the other hand, drugs with low extraction ratios may be impacted by plasma protein binding, although the extent of this influence depends on the fraction of the drug bound.
For low-extraction-ratio drugs that are less than 80% protein-bound, minor changes in protein binding...
326
Lipid-Lowering Drugs: Statins and Miscellaneous Agents01:20

Lipid-Lowering Drugs: Statins and Miscellaneous Agents

Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
925
Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
1.1K
Cholesterol: Significance and Regulation01:29

Cholesterol: Significance and Regulation

Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
726