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Modified microvessel density based on perfusion distance: a preferable NSCLC prognostic factor.

Yinghui Tong1, Dihong Yang1, Xiufang Mi1

  • 1The Department of Pharmacy, The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, Hangzhou, China.

Annals of Translational Medicine
|March 14, 2022
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Summary

Modified microvessel density (mMVD), accounting for perfusion distance, shows superior prognostic value for non-small cell lung cancer (NSCLC) patients compared to traditional markers. High mMVD predicts better overall and progression-free survival.

Keywords:
Non-small cell lung cancer (NSCLC)microvessel densitymicrovessel distanceprognosis markervascular perfusion distance

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Area of Science:

  • Oncology
  • Cancer Research
  • Tumor Microenvironment

Background:

  • The prognostic significance of traditional blood perfusion markers like microvessel density (MVD) in non-small cell lung cancer (NSCLC) remains uncertain.
  • Tumor blood perfusion is critical for cancer progression.

Purpose of the Study:

  • To establish a modified microvessel density (mMVD) measurement incorporating perfusion distance.
  • To determine the prognostic value of this novel mMVD in NSCLC patients.

Main Methods:

  • Retrospective analysis of 100 NSCLC patients.
  • Immunohistochemical staining for CD31 to visualize microvessels.
  • Evaluation of blood perfusion distance (Dmvcc) and calculation of mMVD based on a cutoff value (~20 µm).

Main Results:

  • Modified MVD (mMVD) showed a significantly larger role in predicting overall survival (OS) compared to total MVD (tMVD) (80% vs. 2.9%).
  • mMVD demonstrated superior predictive accuracy (AUC 0.74 vs. 0.56 for tMVD).
  • High mMVD independently predicted improved OS and progression-free survival (PFS), while tMVD was only related to PFS.

Conclusions:

  • Perfusion-distance-based mMVD is a promising prognostic factor for NSCLC patients.
  • mMVD offers superior sensitivity, specificity, and clinical applicability over tMVD.
  • This study offers new insights into the prognostic role of tumor vessel perfusion in NSCLC.