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Related Concept Videos

Tissue Transplantation01:24

Tissue Transplantation

546
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
546
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

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Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
858

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Related Experiment Video

Updated: Sep 30, 2025

Murine Corneal Transplantation: A Model to Study the Most Common Form of Solid Organ Transplantation
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Current Perspectives on Corneal Transplantation (Part 2).

Yee Ling Wong1, Siyin Liu1,2, Andrew Walkden1,2

  • 1Manchester Royal Eye Hospital, Manchester University NHS Foundation Trust, Manchester, UK.

Clinical Ophthalmology (Auckland, N.Z.)
|March 14, 2022
PubMed
Summary
This summary is machine-generated.

Corneal transplantation is a vital treatment for blindness, with lamellar keratoplasty now preferred over full thickness procedures. Emerging therapies may reduce the need for donor corneas.

Keywords:
corneal blindnesscorneal transplantationgraft rejectiongraft survivalkeratoplasty

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Area of Science:

  • Ophthalmology
  • Transplantation Surgery
  • Regenerative Medicine

Background:

  • Corneal disease is a significant global cause of blindness.
  • Corneal transplantation is a highly successful organ transplant.
  • Lamellar keratoplasty is now the standard over full thickness procedures.

Purpose of the Study:

  • To review current corneal transplantation techniques.
  • To analyze treatment outcomes and complications.
  • To explore alternatives to donor-dependent keratoplasty.

Main Methods:

  • Comprehensive literature review.
  • Synthesis of data on adult and pediatric corneal transplantation.
  • Summary of emerging therapeutic approaches.

Main Results:

  • Lamellar keratoplasty has become the preferred method.
  • Review covers outcomes and complications for various procedures.
  • Emerging therapies show promise in reducing donor cornea reliance.

Conclusions:

  • Corneal transplantation remains crucial for vision restoration.
  • Lamellar techniques offer improved outcomes.
  • Future research should focus on regenerative approaches to address donor shortages.