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Intersegmental Interactions Give Rise to a Global Network.

Graciela Kearney1, Martina Radice1, Agustín Sanchez Merlinsky1

  • 1Instituto de Fisiología, Biología Molecular y Neurociencias (IFIBYNE-UBA-CONICET), Buenos Aires, Argentina.

Frontiers in Neural Circuits
|March 14, 2022
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Summary
This summary is machine-generated.

Intersegmental interactions in leeches form a basic network for coordinated crawling. However, additional signals are needed to refine and accelerate this motor activity in vivo.

Keywords:
central pattern generatorintersegmental coordinationmotor controlrecurrent inhibitionrhythmic motor pattern

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Area of Science:

  • Neuroscience
  • Animal Behavior
  • Locomotion

Background:

  • Coordinated motor behaviors in animals rely on synchronized activity across body segments.
  • Temporal coordination of segmental neural networks can be influenced by brain, peripheral, or intersegmental signals.
  • Leeches provide a model system for studying intersegmental coordination due to their regular anatomy.

Purpose of the Study:

  • To investigate the role of intersegmental interactions in coordinating crawling behavior in leeches.
  • To analyze the motor patterns of crawling ex vivo and in vivo to understand underlying neural mechanisms.

Main Methods:

  • Studied fictive crawling motor patterns ex vivo in isolated leech ganglia and three-ganglion chains.
  • Compared ex vivo motor patterns with in vivo crawling behavior.
  • Perturbed motor patterns in isolated ganglia to assess the impact on chain preparations.

Main Results:

  • Ex vivo fictive crawling in leech ganglia exhibited rhythmic activity similar to in vivo observations.
  • Three-ganglion chains showed anterior-posterior coordination, indicating intersegmental interactions independent of brain/peripheral input.
  • Segmental central pattern generators formed a coupled network, reducing system flexibility, but intersegmental phase lags were longer than in vivo.

Conclusions:

  • Intersegmental interactions provide a fundamental framework for correlated motor activity during leech crawling.
  • Additional neural signals are necessary in vivo to enhance and expedite the temporal coordination of motor patterns.