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Vitamin C May Improve Left Ventricular Ejection Fraction: A Meta-Analysis.

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|March 14, 2022
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Vitamin C supplementation improved left ventricular ejection fraction (LVEF) in both cardiac and non-cardiac patients. The benefits were more pronounced in individuals with lower baseline LVEF, suggesting a potential therapeutic role for vitamin C in heart failure.

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Area of Science:

  • Cardiology
  • Nutritional Science

Background:

  • Vitamin C deficiency can manifest symptoms similar to heart failure (HF), including fatigue and chest pain.
  • Patients with HF exhibit lower vitamin C levels, with severity correlating to plasma concentrations, independent of dietary intake.
  • Animal studies indicate vitamin C enhances cardiac contractility and efficiency.

Approach:

  • A meta-analysis was conducted on trials investigating the effects of vitamin C on left ventricular ejection fraction (LVEF).
  • Trial quality was assessed, and selected studies were pooled using inverse variance and fixed-effect models.
  • Meta-regression examined the relationship between vitamin C's effect on LVEF and baseline LVEF levels.

Key Points:

  • Vitamin C significantly increased LVEF by 12.0% in cardiac patients and 5.3% in non-cardiac participants.
  • The positive effect of vitamin C on LVEF was inversely associated with baseline LVEF, showing greater benefits at lower levels.
  • Sensitivity analysis confirmed the findings even when excluding methodologically weaker trials.

Conclusions:

  • Vitamin C supplementation demonstrably improves LVEF in both cardiac and non-cardiac conditions.
  • Further research is warranted to explore vitamin C's efficacy in HF patients with low LVEF and low vitamin C status.
  • Investigating varied dosages and administration routes of vitamin C is recommended.