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Related Experiment Video

Updated: Sep 30, 2025

Validation of a Psychosocial Intervention on Body Image in Older People: An Experimental Design
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Early Life Interventions Can Shape Aging.

Andrzej Bartke1, Liou Y Sun2, Xinna Li3

  • 1Department of Internal Medicine, Southern Illinois University School of Medicine, Springfield, IL, United States.

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|March 14, 2022
PubMed
Summary
This summary is machine-generated.

Early life growth hormone (GH) therapy in dwarf mice normalized adult metabolism but reduced longevity. This suggests early interventions can modify aging trajectories, potentially via epigenetic mechanisms.

Keywords:
Developmental Origins of Health and Disease (DOHaD)agingearly life interventionsgrowth hormonehealthspanlifespanmutant micepostnatal development

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Area of Science:

  • Endocrinology
  • Gerontology
  • Epigenetics

Background:

  • Early life environment significantly influences adult phenotype, health, and aging.
  • Hormonal factors during development play a critical role in long-term health outcomes.
  • Growth hormone (GH) deficiency is linked to extended longevity in certain mouse models.

Purpose of the Study:

  • To investigate if early life hormonal interventions can alter the aging process.
  • To examine the effects of growth hormone (GH) replacement therapy on aging in GH-deficient mice.
  • To explore the mechanistic links between early life interventions, metabolism, aging, and longevity.

Main Methods:

  • Utilized Prop1df (Ames dwarf) mice, which are naturally GH deficient and long-lived.
  • Administered twice-daily GH injections to mice between two and eight weeks of age.
  • Assessed adult metabolic characteristics, longevity, and histone H3 modifications.

Main Results:

  • Early life GH replacement therapy normalized key adult metabolic characteristics in Ames dwarf mice.
  • GH treatment significantly reduced the extended longevity typically observed in Ames dwarf mice.
  • These changes were associated with alterations in histone H3 modifications.

Conclusions:

  • Early life interventions, specifically GH therapy, can modify the trajectory of mammalian aging.
  • The observed effects on aging and longevity appear to involve epigenetic phenomena, including histone modifications.
  • Postnatal development and hormonal milieu are critical determinants of adult aging and lifespan.