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COVID-19 Infection and Guillain-Barre Syndrome: A Case Series
Kendal Carpenter1, Ayman Iqbal2, Romil Singh3
1Neurology, Union Health, Terre Haute, USA.
Insights
COVID-19 can cause neurological complications like Guillain-Barre syndrome (GBS). Three patients with GBS after COVID-19 improved with plasmapheresis, suggesting a link that needs further study.
Area of Science:
- Neurology
- Infectious Diseases
Background:
- The COVID-19 pandemic has revealed diverse systemic complications beyond respiratory effects.
- Neurological manifestations, including Guillain-Barre syndrome (GBS), are increasingly recognized.
- Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can impact the nervous system.
Abstract:
The coronavirus disease 2019 (COVID-19) pandemic brought about an unprecedented time. Multiple systemic complications have been recognized with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) as it can do much more than affect the respiratory system. One of the intriguing neurological complications is Guillain-Barre syndrome (GBS). We reviewed three cases in which patients presented with GBS following COVID-19 infection. All three cases had positive lumbar puncture results with albumino-cytological dissociation. Each patient was treated with plasmapheresis and improved clinically. Although an exact causal relationship between COVID-19 and GBS cannot be drawn from this case series alone, it signifies the importance of this complication. It warrants further studies to establish the causal relationship. One should have a high suspicion for acute inflammatory demyelinating polyneuropathy (AIDP) in patients presenting with acute onset of ascending weakness following COVID-19 infection.
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