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Related Concept Videos

Double Resonance Techniques: Overview01:12

Double Resonance Techniques: Overview

328
Double resonance techniques in Nuclear Magnetic Resonance (NMR) spectroscopy involve the simultaneous application of two different frequencies or radiofrequency pulses to manipulate and observe two distinct nuclear spins. One important application of double resonance is spin decoupling, which selectively suppresses coupling with one type of nucleus while observing the NMR signal from another nucleus, simplifying the spectrum and enhancing resolution.
Spin decoupling is usually achieved by...
328
2D NMR: Overview of Heteronuclear Correlation Techniques01:18

2D NMR: Overview of Heteronuclear Correlation Techniques

342
Heteronuclear correlation spectroscopy is an analytical technique that investigates the coupling between different types of nuclei, often a proton and an X-nucleus, such as carbon-13 or nitrogen-15. This method is commonly used in nuclear magnetic resonance (NMR) spectroscopy to gain insights into complex chemical compounds' structural and compositional aspects. A typical heteronuclear correlation spectrum displays X-nucleus chemical shifts on one axis and a proton spectrum on the other...
342
2D NMR: Overview of Homonuclear Correlation Techniques01:16

2D NMR: Overview of Homonuclear Correlation Techniques

317
Homonuclear correlation spectroscopy (COSY) is a powerful technique used in Nuclear Magnetic Resonance (NMR) spectroscopy to study the correlations between nuclei of the same type within a molecule. It provides information about scalar couplings between adjacent nuclei, which helps determine connectivity and structural information. There are several COSY variants, each with its unique strengths and experimental parameters.
COSY90 is the standard two-dimensional (2D) COSY experiment that...
317
Applications Of NMR In Biology01:25

Applications Of NMR In Biology

4.0K
Nuclear magnetic resonance (NMR) spectroscopy is a very valuable analytical technique for researchers. It has been used for more than 50 years as an analytical tool. F. Bloch and E. Purcell formulated NMR in 1946 and won the 1952 Nobel Prize in Physics  for their work. Biological macromolecules such as proteins, nucleic acids, lipids, and organic molecules including pharmaceutical compounds, can be studied using this versatile tool that exploits the magnetic properties of certain nuclei.
4.0K

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Updated: Sep 30, 2025

Hyperpolarized Xenon for NMR and MRI Applications
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Synergies between Hyperpolarized NMR and Microfluidics: A Review.

James Eills1, William Hale2, Marcel Utz3

  • 1Institute for Physics, Johannes Gutenberg University, D-55090 Mainz, Germany; GSI Helmholtzzentrum für Schwerionenforschung GmbH, Helmholtz-Institut Mainz, 55128 Mainz, Germany.

Progress in Nuclear Magnetic Resonance Spectroscopy
|March 14, 2022
PubMed
Summary

Hyperpolarized nuclear magnetic resonance (NMR) combined with microfluidics enhances sensitivity for biological and chemical analysis. This synergy enables advanced medical diagnostics and research on a single platform.

Keywords:
HyperpolarizationLab-on-a-chipMicrofluidicsNMR

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Area of Science:

  • Biotechnology
  • Spectroscopy
  • Analytical Chemistry

Background:

  • Hyperpolarized nuclear magnetic resonance (NMR) and microfluidics are distinct research fields.
  • Recent advancements have increased their synergistic overlap.
  • Microfluidic integration offers a single platform for complex experimental steps.

Purpose of the Study:

  • To examine the confluence between hyperpolarization-enhanced NMR and microfluidics.
  • To assess the mutual benefits and future potential of these combined technologies.

Main Methods:

  • Microfluidic integration of experimental steps.
  • Application of hyperpolarization techniques to enhance NMR sensitivity.
  • Utilizing microfluidic devices for cell culturing and organ-on-a-chip models.

Main Results:

  • Hyperpolarization can enhance NMR signals by up to 5 orders of magnitude.
  • Microfluidic implementation benefits hyperpolarization methodologies.
  • NMR is well-suited for real-time monitoring in microfluidic systems.

Conclusions:

  • The integration of hyperpolarized NMR and microfluidics significantly extends the utility of NMR in microfluidic systems.
  • This synergy holds promise for advancements in medical diagnostics, forensic analysis, and biomedical research.
  • Continued research will further explore the mutual benefits of these converging fields.