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Updated: Sep 30, 2025

Levator Auris Longus Preparation for Examination of Mammalian Neuromuscular Transmission Under Voltage Clamp Conditions
Published on: May 5, 2018
Mechanisms of the end-plate potential noise and its implication for the neuromuscular junction anatomy
Jia-Zeng Wang1, Zhuo-Jun Shen1
1School of Mathematics and Statistics, Beijing Technology and Business University, Beijing 100048, PR China.
Abstract:
We construct a compact model to mimic the membrane voltage response to the concentration of acetylcholine ([ACh]) which is mediated by the stochastic gating of acetylcholine (ACh) receptors. The patterns of the voltage depolarization against [ACh] as well as the accompanying voltage noises are presented. The mechanism of the voltage fluctuation that caused by the stochastic gating of receptors is explained. We consider that our results explain the frequently observed "end-plate (potential) noise" in physiology and electromyographic literature. These results, together with the requirements of evolution pressure on the motor units, explain reasonably the anatomical structure of the neuromuscular junction.
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