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Related Concept Videos

Aortic Regurgitation III: Medical Management01:25

Aortic Regurgitation III: Medical Management

57
Aortic regurgitation (AR) is when the aortic valve does not close or seal properly, leading to backward blood circulation from the aorta into the left ventricle during diastole. Common causes of AR include rheumatic heart disease, congenital valve defects, and aortic root dilation. Managing AR requires a multifaceted approach to alleviate symptoms, preserve left ventricular function, and address the underlying cause of the regurgitation. Patients with symptomatic AR or significant left...
57
Aortic Regurgitation I: Introduction01:15

Aortic Regurgitation I: Introduction

61
IntroductionAortic regurgitation is characterized by the backward flow of blood from the aorta into the left ventricle during diastole and arises from the improper closure of the aortic valve. This condition results in left ventricular volume overload and can stem from both acute and chronic etiologies, each contributing uniquely to the disease's progression and symptomatology.Acute and Chronic CausesAcute aortic regurgitation often results from events that suddenly impair the integrity of the...
61

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Related Experiment Video

Updated: Sep 30, 2025

Upper-extremity Approach for Secondary Access in Transfemoral Transcatheter Aortic Valve Implantation
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Upper-extremity Approach for Secondary Access in Transfemoral Transcatheter Aortic Valve Implantation

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Pacemaker risk following transcatheter aortic valve replacement - A Bayesian reanalysis.

Arthur M Albuquerque1, James M Brophy2

  • 1School of Medicine, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.

International Journal of Cardiology
|March 14, 2022
PubMed
Summary

This study reanalyzed mortality risk in transcatheter aortic valve replacement (TAVR) patients needing pacemakers. Bayesian analysis indicates a moderate to high probability of increased total mortality in these patients.

Keywords:
BayesianMortalityPacemaker

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Area of Science:

  • Cardiology
  • Biostatistics
  • Medical Informatics

Background:

  • Previous studies found no significant mortality difference in TAVR patients with pacemakers.
  • Bayesian reanalysis may offer deeper insights into mortality risks.

Purpose of the Study:

  • To estimate the probability of increased total mortality risk in patients receiving a cardiac pacemaker after transcatheter aortic valve replacement (TAVR).

Main Methods:

  • Reconstructed individual patient data from Kaplan-Meier curves.
  • Performed Bayesian survival analyses with various priors (vague, skeptical, informative).

Main Results:

  • Reconstructed data showed a 4-year HR of 1.08 (95% CrI 0.85-1.36).
  • Bayesian analysis with a vague prior indicated a 74.9% probability of increased mortality.
  • Informative priors increased the probability of increased mortality to 98.4%.

Conclusions:

  • Bayesian reanalysis suggests a moderate to high probability of increased total mortality.
  • TAVR patients requiring post-procedural pacemaker implantation may face higher mortality risks.