Related Experiment Video
Updated: Sep 30, 2025

Highly Sensitive Measurement of Glomerular Permeability in Mice with Fluorescein Isothiocyanate-polysucrose 70
Published on: August 9, 2019
Tubulointerstitial Nephritis after Using a Sodium-glucose Cotransporter 2 Inhibitor
Yusuke Konta1, Eiichiro Saito1, Koji Sato1
1Department of Internal Medicine, Sendai City Hospital, Japan.
Abstract:
We herein report a case of acute kidney injury (AKI) due to tubulointerstitial nephritis (TIN) after starting empagliflozin in a diabetic patient. The patient developed stage 1 AKI with proteinuria and elevated tubulointerstitial markers. A renal biopsy showed acute TIN with lymphocytic infiltration into the interstitium. The patient's renal function improved after discontinuation of empagliflozin and steroid administration. Sodium-glucose cotransporter 2 (SGLT2) inhibitor-induced AKI has been reported, but the underlying mechanism remains unclear, potentially because few patients with SGLT2-inhibitor-induced AKI have undergone a renal biopsy. We report the present case in the hope that it will help clarify the mechanism.
Related Concept Videos
Glucose Transporters
Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes:
Kidney Transplant II: Surgical Procedure
Glucose Absorption Into the Small Intestine
Secondary Active Transport
Nephrotic Syndrome I : Introduction
Acute Kidney Injury II: Pathophysiology

