Clinical-Dermoscopic-Histopathological Correlations in Collision Skin Tumours

Area of Science:

• Dermatology
• Oncology
• Pathology

Background:

• Collision tumors are rare occurrences involving two distinct skin neoplasms within a single lesion.
• Accurate diagnosis is crucial as malignant components can be overlooked.

Purpose of the Study:

• To analyze clinical, dermoscopic, and histopathological features of 41 collision skin tumors.
• To evaluate the diagnostic challenges and the role of dermoscopy.

Main Methods:

• Retrospective analysis of 41 collision skin tumor cases.
• Correlation of clinical presentation, dermoscopic findings, and histopathological results.

Main Results:

• The study included 41 collision tumors with a mean patient age of 67.9 years and lesion diameter of 11.6 mm.
• Common tumor types included seborrheic keratosis, malignant melanoma, melanocytic nevus, basal cell carcinoma, and hemangioma.
• Malignant tumors were present in 28 cases, often larger and dominant, and over half of collisions were unexpected clinically; six were missed histopathologically.

Conclusions:

• Collision tumors pose diagnostic challenges, frequently missed in initial clinical and histopathological assessments.
• Dermoscopy is a valuable tool for recognizing difficult collision tumor cases.
• Collaboration between dermoscopy and histopathology enhances diagnostic accuracy.