Percutaneous transplantation of pulverized bone in rabbits

The effects of percutaneous injection of the pulverized bone on osteogenesis at the site of bone defect were investigated in rabbits. Although the ceramic bone mixed with blood coagula showed the osteogenic capacity in fresh bone defects, it did not show this capacity in old bone defect. Injection of pulverized bone mixed with blood coagula resulted in greater bone formation than did pulverized bone mixed with saline. Three types of pulverized bone were used: ceramic bone, Kiel bone and autologous corticocancellous bone. Ceramic bone showed the greatest capacity in osteogenesis. These results suggest that the percutaneous injection of pulverized ceramic bone is effective in the treatment of fresh bone defects.