Related Experiment Video

Updated: Sep 30, 2025

Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation
15:04

Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation

Published on: January 19, 2019

12.4K

Combinational therapeutics to combat cancer

Ahmed Al Otaibi1, Subuhi Sherwani2, Eida Mohammed Alshammari1

  • 1Department of Chemistry, College of Sciences, University of Hail, Hail-2440, Saudi Arabia.

Bioinformation
|March 14, 2022
PubMed

Insights

Single treatments often fail for aggressive cancers. Combining therapies, like human gamma delta T cells with anti-cancer molecules, offers a promising strategy to improve treatment efficacy and patient survival by targeting multiple cancer pathways.

Area of Science:

  • Oncology
  • Immunotherapy
  • Cancer Therapeutics

Background:

  • Monotherapy is often ineffective for advanced aggressive cancers, limiting patient survival.
  • Combinational therapeutics, targeting multiple cancer pathways, are increasingly important in cancer treatment.
  • Synergistic effects of combined agents can enhance therapeutic efficacy and potency.

Purpose of the Study:

  • To review existing data on combinational therapeutics for cancer treatment.
  • To highlight the potential of combining human gamma delta T cells with anti-cancer molecules.
  • To discuss the synergistic mechanisms of these combined therapeutic approaches.

Main Methods:

  • Literature review of existing studies on cancer combinational therapy.
  • Focus on studies involving human gamma delta T cells.
  • Analysis of biologically active anti-cancer molecules used in combination therapies.

Main Results:

  • Combinational therapies demonstrate enhanced efficacy compared to monotherapies.
  • Human gamma delta T cells show promise when combined with anti-cancer agents.
  • Synergistic interactions can overcome cancer cell proliferation and metastasis.

Conclusions:

  • Combinational therapeutics represent a significant advancement in cancer treatment.
  • The combination of human gamma delta T cells and anti-cancer molecules offers a promising synergistic approach.
  • Further research into these combinations may lead to improved outcomes for aggressive cancers.
Keywords:
T cellsbiologically active moleculescancercombinational therapeuticssynergistic

More Related Videos

A Data Integration Workflow to Identify Drug Combinations Targeting Synthetic Lethal Interactions07:40

A Data Integration Workflow to Identify Drug Combinations Targeting Synthetic Lethal Interactions

Published on: May 27, 2021

4.3K
A Rapid Screening Workflow to Identify Potential Combination Therapy for GBM using Patient-Derived Glioma Stem Cells05:29

A Rapid Screening Workflow to Identify Potential Combination Therapy for GBM using Patient-Derived Glioma Stem Cells

Published on: March 28, 2021

2.9K

Related Concept Videos

Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.1K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.9K
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
8.0K
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
702
Combined Effects of Drugs: Synergism01:27

Combined Effects of Drugs: Synergism

Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...
5.0K
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.4K