Anti-viral triterpenes: a review

Area of Science:

• Natural Product Chemistry
• Virology
• Medicinal Chemistry

Background:

• Triterpenes are a diverse class of natural products derived from isoprene units.
• These compounds are known for a broad spectrum of biological activities, including significant antiviral potential.
• Recent research has focused on elucidating and harnessing these antiviral properties.

Purpose of the Study:

• To review and synthesize recent scientific literature (2010-2020) on the antiviral activities of triterpenes.
• To examine the structure-activity relationships (SAR) of triterpenes concerning their antiviral efficacy.
• To provide a concise overview of the biosynthesis pathways of these important natural compounds.

Main Methods:

• Comprehensive literature search of scientific databases for studies published between 2010 and 2020.
• Analysis and categorization of identified studies based on triterpene structure and reported antiviral activity.
• Review of studies detailing structure-activity relationship investigations and biosynthetic pathways.

Main Results:

• A significant number of triterpenes exhibit potent antiviral activities against various viruses.
• Specific structural motifs within triterpenes are correlated with enhanced antiviral efficacy.
• Key biosynthetic pathways for the production of antiviral triterpenes have been identified.

Conclusions:

• Triterpenes represent a promising class of natural compounds for the development of novel antiviral therapeutics.
• Further research into SAR and biosynthesis can guide the design of more effective antiviral agents.
• The reviewed literature underscores the therapeutic potential of triterpenes in combating viral infections.