Optimal Parameters of Laser Therapy to Improve Critical Calvarial Defects
Matheus Afm Santos1, Daniela N Silva1, Karla Rovaris2
1Dentistry Graduate Program, Federal University of Espirito Santo, UFES, Vitoria, Brazil.
Frontiers in Physiology
|March 14, 2022
Summary
Low-level laser therapy (LT) combined with inorganic bovine bone (IBB) significantly enhances calvarial defect repair in rats. Seven LT sessions with IBB proved optimal for bone regeneration and mineralization.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Surgical Innovation
Background:
- Calvarial defects pose challenges to integrative physiology, potentially impacting brain function.
- Inorganic bovine bone (IBB) and low-level laser therapy (LT) are promising but require further investigation for optimizing bone defect repair.
Purpose of the Study:
- To determine the optimal number of low-level laser therapy (LT) sessions for accelerating and intensifying calvarial defect recovery.
- To evaluate the combined efficacy of inorganic bovine bone (IBB) and LT in promoting bone regeneration.
Main Methods:
- Created two 5-mm calvarial defects in Wistar rats.
- Utilized blood clot filling and inorganic bovine bone (IBB) for defect repair.
- Applied varying numbers of low-level laser therapy (LT) sessions (4, 7, 11) to subgroups.
Main Results:
- LT sessions did not significantly influence repair in blood clot-filled defects.
- IBB-filled defects showed marked improvement with increasing LT sessions.
- Mineralization increased by 25%, 49%, and 52% with 4, 7, and 11 LT sessions, respectively, compared to controls.
Conclusions:
- Combining inorganic bovine bone (IBB) with seven sessions of low-level laser therapy (LT) is an optimal strategy for enhancing calvarial defect repair.
- This approach offers potential for improved outcomes in patients with large bone traumas, preserving neurological function.
