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Related Concept Videos

Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

217
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
217
Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

500
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
500
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

349
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
349
Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

258
Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
258
Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

487
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
487

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Updated: Sep 30, 2025

A Microscopic Phenotypic Assay for the Quantification of Intracellular Mycobacteria Adapted for High-throughput/High-content Screening
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Contribution and Future of High-Throughput Transcriptomics in Battling Tuberculosis.

Amparo Martínez-Pérez1,2, Olivia Estévez1,2, África González-Fernández1,2

  • 1Biomedical Research Center (CINBIO), Universidade de Vigo, Vigo, Spain.

Frontiers in Microbiology
|March 14, 2022
PubMed
Summary

Tuberculosis (TB) research benefits from transcriptomics, analyzing gene expression for diagnosis and treatment. Challenges in cost and interpretation remain for full implementation in TB care.

Keywords:
RNA-sequencingdrug resistanceimmune responsemicroarraymycobacteriatranscriptomicstuberculosis

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Area of Science:

  • Microbiology and Immunology
  • Genomics and Bioinformatics

Background:

  • Tuberculosis (TB) remains a significant global health challenge.
  • Big data and omics approaches, particularly transcriptomics, are advancing TB understanding.

Purpose of the Study:

  • To review the applications of transcriptomics in TB research.
  • To identify challenges hindering the clinical implementation of transcriptomics in TB.

Main Methods:

  • Review of existing literature on transcriptomics in Tuberculosis.
  • Analysis of key research areas and challenges in the field.

Main Results:

  • Transcriptomics has been applied to TB diagnosis, treatment monitoring, latency, novel target discovery, and vaccine response.
  • Key challenges include high costs and complex data interpretation.

Conclusions:

  • Transcriptomics offers valuable insights into TB pathogenesis and host response.
  • Technological advancements and interdisciplinary collaboration are crucial for overcoming current limitations and enabling clinical utility.