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Th1, Th2 and Th17 inflammatory pathways synergistically predict cardiometabolic protein expression in serum of

James R Michels1, Mohammad Shaheed Nazrul2, Sudeep Adhikari3

  • 1Biomedical Engineering, University of Mississippi, University, MS, USA. apavel@olemiss.edu.

Molecular Omics
|March 14, 2022
PubMed

Insights

Severe inflammation in COVID-19 patients links to heart issues. Helper T-cell pathways (Th1, Th2, Th17) predict cardiometabolic proteins, offering insights into disease complications and potential treatments.

Area of Science:

  • Immunology
  • Cardiology
  • Virology

Background:

  • Severe systemic inflammation is a primary complication in SARS-CoV-2 (COVID-19) patients, frequently leading to tissue damage, organ failure, and cardiovascular comorbidities.
  • Understanding the interplay between immune responses and cardiovascular health is crucial for improving medical decisions and therapeutic strategies in COVID-19 management.

Purpose of the Study:

  • To investigate the synergistic correlation between helper T-cell inflammatory pathways (Th1, Th2, and Th17) and cardiometabolic proteins in the serum of COVID-19 patients.
  • To determine if specific immune signaling molecules can predict the expression levels of cardiometabolic proteins.

Main Methods:

  • Serum samples from COVID-19 patients were analyzed.
  • Cytokine and chemokine levels associated with Th1, Th2, and Th17 pathways were measured.
  • Olink proteomics was employed to profile the expression of 186 cardiometabolic proteins.

Main Results:

  • A significant correlation was observed between Th1, Th2, and Th17 pathway cytokines and chemokines and the expression of 186 cardiometabolic proteins.
  • These inflammatory markers demonstrated predictive capability for the expression levels of numerous cardiometabolic proteins.

Conclusions:

  • Helper T-cell mediated inflammatory pathways are strongly associated with cardiometabolic protein expression in COVID-19.
  • The findings suggest that immune dysregulation in COVID-19 directly impacts cardiovascular-related protein profiles, potentially identifying new therapeutic targets.

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