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Complete Genome Sequence of Stenotrophomonas maltophilia Podophage Ptah

Amelia Berg1, Nathaniel Tate1, James Clark1,2

  • 1Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas, USA.

Microbiology Resource Announcements
|March 14, 2022
PubMed

Insights

The genome of Stenotrophomonas maltophilia podophage Ptah was sequenced and analyzed. This bacteriophage is closely related to other T7-like phages that infect drug-resistant bacteria.

Area of Science:

  • Microbiology
  • Virology
  • Genomics

Background:

  • Stenotrophomonas maltophilia is an opportunistic pathogen.
  • Increasing drug resistance in S. maltophilia poses a significant clinical challenge.
  • Bacteriophages offer potential therapeutic strategies against resistant bacteria.

Purpose of the Study:

  • To describe the genome of the T7-like S. maltophilia podophage Ptah.
  • To compare the Ptah phage genome with related phages.

Main Methods:

  • Genome sequencing of the S. maltophilia podophage Ptah.
  • Bioinformatic analysis of the phage genome.

Main Results:

  • The complete genome of Ptah was determined to be 42,593 bp.
  • The Ptah genome shows close genetic relatedness to previously identified T7-like S. maltophilia podophages, such as phage Ponderosa.

Conclusions:

  • The characterization of the Ptah phage genome contributes to understanding the diversity of S. maltophilia phages.
  • This genomic information may aid in the development of phage-based therapies against drug-resistant S. maltophilia infections.

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