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Updated: Sep 30, 2025

PIP-on-a-chip: A Label-free Study of Protein-phosphoinositide Interactions
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Correlation between structure and function in phosphatidylinositol lipid-dependent Kir2.2 gating

Yuxi Zhang1, Xiao Tao1, Roderick MacKinnon1

  • 1Laboratory of Molecular Neurobiology and Biophysics, HHMI, The Rockefeller University, New York, NY ,10065.

Proceedings of the National Academy of Sciences of the United States of America
|March 14, 2022
PubMed
Summary

Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) regulates cell membrane voltage by controlling K+ channel activity. Phosphatidylinositol 4-phosphate (PI4P) competes with this lipid, suggesting a dual role in channel regulation.

Keywords:
PI(4)PPI(4,5)P2inward rectifierphosphatidylinositol lipidsingle-channel analysis

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