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Published on: November 7, 2017
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Cardiac involvement in pediatric hemolytic uremic syndrome
Corentin Tanné1,2, Etienne Javouhey3,4, Olivia Boyer5,6
1Department of Pediatric Nephrology, Hopital Femme-Mere-Enfant, Lyon, France.
Pediatric Nephrology (Berlin, Germany)
|March 14, 2022
Summary
Pediatric hemolytic uremic syndrome (HUS) can rarely cause myocarditis. This study found higher leukocyte counts and platelet transfusions were associated with myocarditis in HUS patients, which has a high fatality rate.
Area of Science:
- Pediatric Cardiology
- Nephrology
- Intensive Care Medicine
Background:
- Cardiac involvement, specifically myocarditis, is a rare but serious complication of pediatric hemolytic uremic syndrome (HUS).
- Understanding factors associated with myocarditis in HUS is crucial for early detection and management.
Purpose of the Study:
- To identify factors associated with the occurrence of myocarditis in children diagnosed with hemolytic uremic syndrome.
- To describe the clinical characteristics and outcomes of pediatric HUS patients with myocarditis.
Main Methods:
- A nationwide, retrospective, case-control study was conducted.
- Cases were HUS patients with myocarditis, and controls were HUS patients without myocarditis, admitted to French Pediatric Intensive Care Units (PICUs) between 2007 and 2018.
Main Results:
- Twenty cases of myocarditis were identified among HUS patients.
- Maximal leukocyte count was significantly higher in the myocarditis group (29.1 vs. 21.0 G/L).
- The fatality rate was substantially higher in the myocarditis group (40.0%) compared to controls (1.5%), with platelet transfusion being more frequent in cases (65% vs. 29%).
Conclusions:
- Myocarditis in pediatric HUS is associated with a high fatality rate.
- Elevated leukocyte count and the administration of platelet transfusions may be risk factors for developing myocarditis in HUS patients.
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