Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Disorders of the Male Reproductive System01:20

Disorders of the Male Reproductive System

1.1K
Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
1.1K
Spermatogenesis01:41

Spermatogenesis

103.8K
Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male...
103.8K
Infertility in Males01:23

Infertility in Males

345
Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
345
Testosterone: Functions and Regulation01:26

Testosterone: Functions and Regulation

1.1K
The intricate hormonal interplay essential for male reproductive health begins with the release of gonadotropin-releasing hormone (GnRH) by the hypothalamus. This hormone prompts the pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). LH targets the Leydig cells in the testes, stimulating them to produce and release testosterone. In concert with testosterone, FSH acts on the Sertoli cells within the seminiferous tubules to facilitate the release of...
1.1K
Signs of Puberty01:27

Signs of Puberty

696
Puberty is a critical phase, typically beginning between the ages of 8 and 13 in girls and 9 and 14 in boys, though timing can vary based on genetics, environmental factors, and overall health. This period is characterized by the development of secondary sexual characteristics and the attainment of reproductive potential. Endocrine changes underpin puberty, with hormonal surges of Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH) instigated by Gonadotropin-Releasing Hormone (GnRH)...
696
Testes: Histology01:27

Testes: Histology

1.7K
A tough, fibrous membrane, the tunica albuginea, covers the testes, extending inward to form fibrous partitions or septa, dividing them into internal compartments called lobules. Each lobule has 1 to 3 tightly coiled seminiferous tubules where sperm production occurs. These tubules merge into a tubular network at the back of the testis, known as the rete testis. It connects to 15 to 20 efferent ductules, leading to the epididymis.
The spermatogenic cells, responsible for producing sperm, are...
1.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sperm Imprinted Gene Methylation and DNA Fragmentation in ICSI Outcomes: A Pilot Study.

Epigenomes·2026
Same author

Semen Cryopreservation in Testicular Cancer: Before or After Orchidectomy?

Andrology·2026
Same author

Machine Learning Evaluation of Semen Analysis Could Reveal New Infertility-Related Markers: A Pilot Study.

The world journal of men's health·2026
Same author

Male hypogonadism in transition age: fertility outcomes and practical management.

Endocrine·2025
Same author

Correction: Mediterranean diet, selenium and Graves' ophthalmopathy: a prospective, randomized, single-center study.

Endocrine·2025
Same author

Mediterranean diet, selenium and Graves' ophthalmopathy: a prospective, randomized, single-center study.

Endocrine·2025
Same journal

Adult mice are more susceptible to high-fat diet-induced visceral adiposity and insulin resistance than juvenile mice.

Journal of endocrinological investigation·2026
Same journal

Lactobacillus gasseri alleviates type 2 diabetes via modulation of gut microbiota-host metabolic networks.

Journal of endocrinological investigation·2026
Same journal

Rare causes of exogenous Cushing's Syndrome: a challenge for endocrinologists.

Journal of endocrinological investigation·2026
Same journal

Phase angle and triglyceride-glucose index as biomarkers of glycemic control, body composition and cardiovascular risk in adolescents with type 1 diabetes: a cross-sectional study.

Journal of endocrinological investigation·2026
Same journal

4-Methylumbelliferone for type 1 diabetes therapy: evidence for β-cell protection via EGFR/PI3K/Akt signaling.

Journal of endocrinological investigation·2026
Same journal

Testosterone replacement therapy and cardiovascular safety in older men: lessons from TRAVERSE and beyond.

Journal of endocrinological investigation·2026
See all related articles

Related Experiment Video

Updated: Sep 30, 2025

Author Spotlight: Understanding Adolescent Social Adversity Effects on Neurodevelopment in Mice
07:15

Author Spotlight: Understanding Adolescent Social Adversity Effects on Neurodevelopment in Mice

Published on: March 15, 2024

1.8K

Risk factors on testicular function in adolescents.

F Cargnelutti1, A Di Nisio2, F Pallotti1

  • 1Laboratory of Seminology-Sperm Bank "Loredana Gandini", Department of Experimental Medicine, "Sapienza" University of Rome, Viale del Policlinico 155, 00161, Rome, Italy.

Journal of Endocrinological Investigation
|March 14, 2022
PubMed
Summary
This summary is machine-generated.

Male adolescents face numerous testicular health risks from factors like obesity and substance use, potentially impacting adult fertility. Early intervention during adolescence is crucial for preventing future male infertility and hypogonadism.

Keywords:
CancerCryptorchidismDiabetesObesityPubertyVaricocele

More Related Videos

Isolation of Sertoli Cells and Peritubular Cells from Rat Testes
11:11

Isolation of Sertoli Cells and Peritubular Cells from Rat Testes

Published on: February 8, 2016

22.8K
A Modified Trier Social Stress Test for Vulnerable Mexican American Adolescents
06:15

A Modified Trier Social Stress Test for Vulnerable Mexican American Adolescents

Published on: July 10, 2017

13.0K

Related Experiment Videos

Last Updated: Sep 30, 2025

Author Spotlight: Understanding Adolescent Social Adversity Effects on Neurodevelopment in Mice
07:15

Author Spotlight: Understanding Adolescent Social Adversity Effects on Neurodevelopment in Mice

Published on: March 15, 2024

1.8K
Isolation of Sertoli Cells and Peritubular Cells from Rat Testes
11:11

Isolation of Sertoli Cells and Peritubular Cells from Rat Testes

Published on: February 8, 2016

22.8K
A Modified Trier Social Stress Test for Vulnerable Mexican American Adolescents
06:15

A Modified Trier Social Stress Test for Vulnerable Mexican American Adolescents

Published on: July 10, 2017

13.0K

Area of Science:

  • Reproductive Endocrinology
  • Adolescent Health
  • Andrology

Background:

  • Adolescence is a critical period for gonadal development.
  • Understanding risk factors affecting testicular function during this window is vital.
  • Current literature on adolescent testicular health requires critical review.

Purpose of the Study:

  • To review recent literature on endogenous and exogenous risk factors impacting testicular function in adolescents.
  • To critically analyze factors affecting puberty timing and andrological health during adolescence.

Main Methods:

  • Comprehensive literature search of PubMed.
  • Focused on human studies examining varicocele, cryptorchidism, cancer, diabetes, lifestyle, endocrine disruptors, obesity, and STDs.
  • Evaluated impact on puberty timing and andrological health.

Main Results:

  • Andrological health in adolescence can be impaired by varicocele, cryptorchidism, and childhood cancer.
  • Lifestyle factors including obesity, alcohol, smoking, and drug use correlate with testicular dysfunction in pubertal boys.
  • Endocrine disruptors and STDs may affect reproductive health, warranting further adolescent-focused research.

Conclusions:

  • Adolescence is characterized by an increasing trend of unhealthy behaviors in males.
  • Undiagnosed andrological disorders combined with risky behaviors increase the risk of adult infertility and hypogonadism.
  • Adolescence represents a key period for intervention and prevention of future andrological diseases.